Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol
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Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol. / Vinberg, Maj; Mellerup, Erling; Andersen, Per Kragh; Bennike, Bente; Kessing, Lars Vedel.
In: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol. 34, No. 1, 2009, p. 86-91.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol
AU - Vinberg, Maj
AU - Mellerup, Erling
AU - Andersen, Per Kragh
AU - Bennike, Bente
AU - Kessing, Lars Vedel
N1 - Copyright 2009 Elsevier Inc. All rights reserved.
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders. AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol. METHOD: In a high-risk population study, healthy monozygotic and dizygotic twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nationwide registers. RESULTS: When comparing the 81 individuals homozygote for the long allele with the 125 individuals hetero- and homozygote for the short allele no associations between the allele distribution and a genetic predisposition were found. The presence of the short allele of the 5-HTTLPR and the experience of SLE was associated with a higher neuroticism score, but not with depressive symptoms nor awakening or evening salivary cortisol. CONCLUSION: A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.
AB - BACKGROUND: Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders. AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol. METHOD: In a high-risk population study, healthy monozygotic and dizygotic twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nationwide registers. RESULTS: When comparing the 81 individuals homozygote for the long allele with the 125 individuals hetero- and homozygote for the short allele no associations between the allele distribution and a genetic predisposition were found. The presence of the short allele of the 5-HTTLPR and the experience of SLE was associated with a higher neuroticism score, but not with depressive symptoms nor awakening or evening salivary cortisol. CONCLUSION: A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.
U2 - 10.1016/j.pnpbp.2009.10.002
DO - 10.1016/j.pnpbp.2009.10.002
M3 - Journal article
C2 - 19822181
VL - 34
SP - 86
EP - 91
JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry
SN - 0278-5846
IS - 1
ER -
ID: 16914698