Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites
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Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites. / Hamid, Yasmin H; Urhammer, Søren A; Jensen, Dorit P; Glümer, Charlotte; Borch-Johnsen, Knut; Jørgensen, Torben; Hansen, Torben; Pedersen, Oluf.
In: Diabetes, Vol. 53, No. 12, 2004, p. 3342-5.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites
AU - Hamid, Yasmin H
AU - Urhammer, Søren A
AU - Jensen, Dorit P
AU - Glümer, Charlotte
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Hansen, Torben
AU - Pedersen, Oluf
PY - 2004
Y1 - 2004
N2 - Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity. IL-6 signals via a heterodimeric receptor complex consisting of a soluble IL-6 alpha-subunit (IL-6 receptor [IL6R]) and a signal transducing subunit (gp130). The IL6R gene maps to an important candidate locus for type 2 diabetes on chromosome 1q21. An Asp358Ala polymorphism of the IL6R has been reported to associate with obesity in Pima Indians. We investigated the Asp358Ala polymorphism in relation to type 2 diabetes, obesity, and other pre-diabetic quantitative traits among Danish whites. By applying a recessive genetic model in a case-control study of 1,349 type 2 diabetic patients and 4,596 glucose-tolerant control subjects, we found a significant difference in genotype distribution (P = 0.008) and in allele frequency (Ala-allele 38.3% [95% CI 36.5-40.1] in diabetic subjects vs. 41.2% [40.2-42.2] in control subjects; P = 0.007). The odds ratio for the Asp/Asp carriers versus Ala/Ala carriers was 1.38 (1.09-1.71). Among 4,251 middle-aged glucose-tolerant subjects, the Asp358Ala polymorphism was not associated with estimates of obesity, post-oral glucose tolerance test serum insulin release, or the homeostasis model assessment of insulin resistance index. In conclusion, the Asp358Ala polymorphism of the IL6R associates with type 2 diabetes in Danish whites.
AB - Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity. IL-6 signals via a heterodimeric receptor complex consisting of a soluble IL-6 alpha-subunit (IL-6 receptor [IL6R]) and a signal transducing subunit (gp130). The IL6R gene maps to an important candidate locus for type 2 diabetes on chromosome 1q21. An Asp358Ala polymorphism of the IL6R has been reported to associate with obesity in Pima Indians. We investigated the Asp358Ala polymorphism in relation to type 2 diabetes, obesity, and other pre-diabetic quantitative traits among Danish whites. By applying a recessive genetic model in a case-control study of 1,349 type 2 diabetic patients and 4,596 glucose-tolerant control subjects, we found a significant difference in genotype distribution (P = 0.008) and in allele frequency (Ala-allele 38.3% [95% CI 36.5-40.1] in diabetic subjects vs. 41.2% [40.2-42.2] in control subjects; P = 0.007). The odds ratio for the Asp/Asp carriers versus Ala/Ala carriers was 1.38 (1.09-1.71). Among 4,251 middle-aged glucose-tolerant subjects, the Asp358Ala polymorphism was not associated with estimates of obesity, post-oral glucose tolerance test serum insulin release, or the homeostasis model assessment of insulin resistance index. In conclusion, the Asp358Ala polymorphism of the IL6R associates with type 2 diabetes in Danish whites.
KW - Amino Acid Substitution
KW - Chromosome Mapping
KW - Chromosomes, Human, Pair 1
KW - Denmark
KW - Diabetes Mellitus, Type 2
KW - European Continental Ancestry Group
KW - Genetic Variation
KW - Glucose Intolerance
KW - Heterozygote Detection
KW - Humans
KW - Polymorphism, Single Nucleotide
KW - Receptors, Interleukin-6
M3 - Journal article
C2 - 15561970
VL - 53
SP - 3342
EP - 3345
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 12
ER -
ID: 38456983