Validation of diffuse correlation spectroscopy against 15O-water PET for regional cerebral blood flow measurement in neonatal piglets
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Validation of diffuse correlation spectroscopy against 15O-water PET for regional cerebral blood flow measurement in neonatal piglets. / Giovannella, Martina; Andresen, Bjørn; Andersen, Julie B.; El-Mahdaoui, Sahla; Contini, Davide; Spinelli, Lorenzo; Torricelli, Alessandro; Greisen, Gorm; Durduran, Turgut; Weigel, Udo M.; Law, Ian.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 40, No. 10, 2020, p. 2055-2065.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Validation of diffuse correlation spectroscopy against 15O-water PET for regional cerebral blood flow measurement in neonatal piglets
AU - Giovannella, Martina
AU - Andresen, Bjørn
AU - Andersen, Julie B.
AU - El-Mahdaoui, Sahla
AU - Contini, Davide
AU - Spinelli, Lorenzo
AU - Torricelli, Alessandro
AU - Greisen, Gorm
AU - Durduran, Turgut
AU - Weigel, Udo M.
AU - Law, Ian
PY - 2020
Y1 - 2020
N2 - Diffuse correlation spectroscopy (DCS) can non-invasively and continuously asses regional cerebral blood flow (rCBF) at the cot-side by measuring a blood flow index (BFI) in non-traditional units of cm2/s. We have validated DCS against positron emission tomography using 15O-labeled water (15O-water PET) in a piglet model allowing us to derive a conversion formula for BFI to rCBF in conventional units (ml/100g/min). Neonatal piglets were continuously monitored by the BabyLux device integrating DCS and time resolved near infrared spectroscopy (TRS) while acquiring 15O-water PET scans at baseline, after injection of acetazolamide and during induced hypoxic episodes. BFI by DCS was highly correlated with rCBF (R = 0.94, p ' 0.001) by PET. A scaling factor of 0.89 (limits of agreement for individual measurement: 0.56, 1.39)×109× (ml/100g/min)/(cm2/s) was used to derive baseline rCBF from baseline BFI measurements of another group of piglets and of healthy newborn infants showing an agreement with expected values. These results pave the way towards non-invasive, cot-side absolute CBF measurements by DCS on neonates.
AB - Diffuse correlation spectroscopy (DCS) can non-invasively and continuously asses regional cerebral blood flow (rCBF) at the cot-side by measuring a blood flow index (BFI) in non-traditional units of cm2/s. We have validated DCS against positron emission tomography using 15O-labeled water (15O-water PET) in a piglet model allowing us to derive a conversion formula for BFI to rCBF in conventional units (ml/100g/min). Neonatal piglets were continuously monitored by the BabyLux device integrating DCS and time resolved near infrared spectroscopy (TRS) while acquiring 15O-water PET scans at baseline, after injection of acetazolamide and during induced hypoxic episodes. BFI by DCS was highly correlated with rCBF (R = 0.94, p ' 0.001) by PET. A scaling factor of 0.89 (limits of agreement for individual measurement: 0.56, 1.39)×109× (ml/100g/min)/(cm2/s) was used to derive baseline rCBF from baseline BFI measurements of another group of piglets and of healthy newborn infants showing an agreement with expected values. These results pave the way towards non-invasive, cot-side absolute CBF measurements by DCS on neonates.
KW - Cerebral blood flow
KW - continuous neuro-monitoring
KW - diffuse correlation spectroscopy
KW - near-infrared spectroscopy
KW - PET
U2 - 10.1177/0271678X19883751
DO - 10.1177/0271678X19883751
M3 - Journal article
C2 - 31665953
AN - SCOPUS:85074822588
VL - 40
SP - 2055
EP - 2065
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 10
ER -
ID: 258774359