Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus. / Meunier, Jean-Christophe; Gottwein, Judith M; Houghton, Michael; Russell, Rodney S; Emerson, Suzanne U; Bukh, Jens; Purcell, Robert H.

In: Journal of Infectious Diseases, Vol. 204, No. 8, 2011, p. 1186-90.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Meunier, J-C, Gottwein, JM, Houghton, M, Russell, RS, Emerson, SU, Bukh, J & Purcell, RH 2011, 'Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus', Journal of Infectious Diseases, vol. 204, no. 8, pp. 1186-90. https://doi.org/10.1093/infdis/jir511

APA

Meunier, J-C., Gottwein, J. M., Houghton, M., Russell, R. S., Emerson, S. U., Bukh, J., & Purcell, R. H. (2011). Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus. Journal of Infectious Diseases, 204(8), 1186-90. https://doi.org/10.1093/infdis/jir511

Vancouver

Meunier J-C, Gottwein JM, Houghton M, Russell RS, Emerson SU, Bukh J et al. Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus. Journal of Infectious Diseases. 2011;204(8):1186-90. https://doi.org/10.1093/infdis/jir511

Author

Meunier, Jean-Christophe ; Gottwein, Judith M ; Houghton, Michael ; Russell, Rodney S ; Emerson, Suzanne U ; Bukh, Jens ; Purcell, Robert H. / Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus. In: Journal of Infectious Diseases. 2011 ; Vol. 204, No. 8. pp. 1186-90.

Bibtex

@article{9b3b11e807db488ba231510210e71aa2,
title = "Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus",
abstract = "We detected cross-reactive neutralizing antibodies (NtAb) against hepatitis C virus (HCV) in chimpanzees vaccinated with HCV-1 (genotype 1a) recombinant E1/E2 envelope glycoproteins. Five vaccinated chimpanzees, protected following HCV-1 challenge, were initially studied using the heterologous H77 (genotype 1a) HCVpp assay. All animals had developed NtAb after the second vaccination; 4 animals had reciprocal titers of =200 at the time of challenge. Using genotypes 1a-6a HCV pseudoparticles (HCVpp) and cell culture-derived HCV (HCVcc) assays, cross-reactive NtAb were detected against 1a, 4a, 5a, and 6a, with limited reactivity against 2a and 3a. Our study provides encouragement for the development of a recombinant envelope-based vaccine against hepatitis C.",
keywords = "Animals, Antibodies, Neutralizing, Cross Reactions, Flow Cytometry, Genotype, Hepacivirus, Hepatitis C, Chronic, Pan troglodytes, Retrospective Studies, Vaccination, Vaccines, Synthetic, Viral Envelope Proteins, Viral Hepatitis Vaccines",
author = "Jean-Christophe Meunier and Gottwein, {Judith M} and Michael Houghton and Russell, {Rodney S} and Emerson, {Suzanne U} and Jens Bukh and Purcell, {Robert H}",
year = "2011",
doi = "10.1093/infdis/jir511",
language = "English",
volume = "204",
pages = "1186--90",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

AU - Meunier, Jean-Christophe

AU - Gottwein, Judith M

AU - Houghton, Michael

AU - Russell, Rodney S

AU - Emerson, Suzanne U

AU - Bukh, Jens

AU - Purcell, Robert H

PY - 2011

Y1 - 2011

N2 - We detected cross-reactive neutralizing antibodies (NtAb) against hepatitis C virus (HCV) in chimpanzees vaccinated with HCV-1 (genotype 1a) recombinant E1/E2 envelope glycoproteins. Five vaccinated chimpanzees, protected following HCV-1 challenge, were initially studied using the heterologous H77 (genotype 1a) HCVpp assay. All animals had developed NtAb after the second vaccination; 4 animals had reciprocal titers of =200 at the time of challenge. Using genotypes 1a-6a HCV pseudoparticles (HCVpp) and cell culture-derived HCV (HCVcc) assays, cross-reactive NtAb were detected against 1a, 4a, 5a, and 6a, with limited reactivity against 2a and 3a. Our study provides encouragement for the development of a recombinant envelope-based vaccine against hepatitis C.

AB - We detected cross-reactive neutralizing antibodies (NtAb) against hepatitis C virus (HCV) in chimpanzees vaccinated with HCV-1 (genotype 1a) recombinant E1/E2 envelope glycoproteins. Five vaccinated chimpanzees, protected following HCV-1 challenge, were initially studied using the heterologous H77 (genotype 1a) HCVpp assay. All animals had developed NtAb after the second vaccination; 4 animals had reciprocal titers of =200 at the time of challenge. Using genotypes 1a-6a HCV pseudoparticles (HCVpp) and cell culture-derived HCV (HCVcc) assays, cross-reactive NtAb were detected against 1a, 4a, 5a, and 6a, with limited reactivity against 2a and 3a. Our study provides encouragement for the development of a recombinant envelope-based vaccine against hepatitis C.

KW - Animals

KW - Antibodies, Neutralizing

KW - Cross Reactions

KW - Flow Cytometry

KW - Genotype

KW - Hepacivirus

KW - Hepatitis C, Chronic

KW - Pan troglodytes

KW - Retrospective Studies

KW - Vaccination

KW - Vaccines, Synthetic

KW - Viral Envelope Proteins

KW - Viral Hepatitis Vaccines

U2 - 10.1093/infdis/jir511

DO - 10.1093/infdis/jir511

M3 - Journal article

C2 - 21917891

VL - 204

SP - 1186

EP - 1190

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 8

ER -

ID: 40329351