Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation

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Standard

Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation. / Galle, Pia; Jensen, Lene; Andersson, Christina; Cuzzocrea, Salvatore; Di Paola, Rosanna; Nicoletti, Ferdinando; Svenson, Morten; Bendtzen, Klaus; Thomsen, Allan Randrup; Hansen, Morten B.

In: International Immunopharmacology, Vol. 7, No. 13, 2007, p. 1704-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Galle, P, Jensen, L, Andersson, C, Cuzzocrea, S, Di Paola, R, Nicoletti, F, Svenson, M, Bendtzen, K, Thomsen, AR & Hansen, MB 2007, 'Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation', International Immunopharmacology, vol. 7, no. 13, pp. 1704-13. https://doi.org/10.1016/j.intimp.2007.08.026

APA

Galle, P., Jensen, L., Andersson, C., Cuzzocrea, S., Di Paola, R., Nicoletti, F., Svenson, M., Bendtzen, K., Thomsen, A. R., & Hansen, M. B. (2007). Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation. International Immunopharmacology, 7(13), 1704-13. https://doi.org/10.1016/j.intimp.2007.08.026

Vancouver

Galle P, Jensen L, Andersson C, Cuzzocrea S, Di Paola R, Nicoletti F et al. Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation. International Immunopharmacology. 2007;7(13):1704-13. https://doi.org/10.1016/j.intimp.2007.08.026

Author

Galle, Pia ; Jensen, Lene ; Andersson, Christina ; Cuzzocrea, Salvatore ; Di Paola, Rosanna ; Nicoletti, Ferdinando ; Svenson, Morten ; Bendtzen, Klaus ; Thomsen, Allan Randrup ; Hansen, Morten B. / Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation. In: International Immunopharmacology. 2007 ; Vol. 7, No. 13. pp. 1704-13.

Bibtex

@article{9c0d71e0e16b11ddb5fc000ea68e967b,
title = "Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation",
abstract = "IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear healthy and do not exhibit overt clinical or laboratory abnormalities. We induced comparable levels of aAb-IL-6 in different mouse strains by vaccination with immunogenic IL-6 analogues. We observed that the induced aAb-IL-6 protected against collagen-induced arthritis and experimental allergic encephalitis. Furthermore, aAb-IL-6 carrying mice displayed increased plasma TNFalpha concentrations upon challenge with LPS. Taken together, induction of IL-6 autoantibodies was possible in different mouse strains. The autoantibodies influenced experimental inflammation. This immunotherapeutic principle might be a viable alternative in immune competent humans suffering from disorders driven by IL-6.",
keywords = "Animals, Arthritis, Experimental, Autoantibodies, Encephalomyelitis, Autoimmune, Experimental, Interleukin-6, Lipopolysaccharides, Mice, Mice, Inbred Strains, Serum Amyloid A Protein, Tumor Necrosis Factor-alpha, Vaccination",
author = "Pia Galle and Lene Jensen and Christina Andersson and Salvatore Cuzzocrea and {Di Paola}, Rosanna and Ferdinando Nicoletti and Morten Svenson and Klaus Bendtzen and Thomsen, {Allan Randrup} and Hansen, {Morten B}",
note = "Keywords: Animals; Arthritis, Experimental; Autoantibodies; Encephalomyelitis, Autoimmune, Experimental; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred Strains; Serum Amyloid A Protein; Tumor Necrosis Factor-alpha; Vaccination",
year = "2007",
doi = "10.1016/j.intimp.2007.08.026",
language = "English",
volume = "7",
pages = "1704--13",
journal = "International Immunopharmacology",
issn = "1567-5769",
publisher = "Elsevier",
number = "13",

}

RIS

TY - JOUR

T1 - Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation

AU - Galle, Pia

AU - Jensen, Lene

AU - Andersson, Christina

AU - Cuzzocrea, Salvatore

AU - Di Paola, Rosanna

AU - Nicoletti, Ferdinando

AU - Svenson, Morten

AU - Bendtzen, Klaus

AU - Thomsen, Allan Randrup

AU - Hansen, Morten B

N1 - Keywords: Animals; Arthritis, Experimental; Autoantibodies; Encephalomyelitis, Autoimmune, Experimental; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred Strains; Serum Amyloid A Protein; Tumor Necrosis Factor-alpha; Vaccination

PY - 2007

Y1 - 2007

N2 - IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear healthy and do not exhibit overt clinical or laboratory abnormalities. We induced comparable levels of aAb-IL-6 in different mouse strains by vaccination with immunogenic IL-6 analogues. We observed that the induced aAb-IL-6 protected against collagen-induced arthritis and experimental allergic encephalitis. Furthermore, aAb-IL-6 carrying mice displayed increased plasma TNFalpha concentrations upon challenge with LPS. Taken together, induction of IL-6 autoantibodies was possible in different mouse strains. The autoantibodies influenced experimental inflammation. This immunotherapeutic principle might be a viable alternative in immune competent humans suffering from disorders driven by IL-6.

AB - IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear healthy and do not exhibit overt clinical or laboratory abnormalities. We induced comparable levels of aAb-IL-6 in different mouse strains by vaccination with immunogenic IL-6 analogues. We observed that the induced aAb-IL-6 protected against collagen-induced arthritis and experimental allergic encephalitis. Furthermore, aAb-IL-6 carrying mice displayed increased plasma TNFalpha concentrations upon challenge with LPS. Taken together, induction of IL-6 autoantibodies was possible in different mouse strains. The autoantibodies influenced experimental inflammation. This immunotherapeutic principle might be a viable alternative in immune competent humans suffering from disorders driven by IL-6.

KW - Animals

KW - Arthritis, Experimental

KW - Autoantibodies

KW - Encephalomyelitis, Autoimmune, Experimental

KW - Interleukin-6

KW - Lipopolysaccharides

KW - Mice

KW - Mice, Inbred Strains

KW - Serum Amyloid A Protein

KW - Tumor Necrosis Factor-alpha

KW - Vaccination

U2 - 10.1016/j.intimp.2007.08.026

DO - 10.1016/j.intimp.2007.08.026

M3 - Journal article

C2 - 17996680

VL - 7

SP - 1704

EP - 1713

JO - International Immunopharmacology

JF - International Immunopharmacology

SN - 1567-5769

IS - 13

ER -

ID: 9701179