Use of thyroid hormones in relation to pregnancy: a Danish nationwide cohort study
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Use of thyroid hormones in relation to pregnancy : a Danish nationwide cohort study. / Gidén, Karin; Andersen, Jon Traerup; Torp-Pedersen, Arendse Laerke; Enghusen Poulsen, Henrik; Torp-Pedersen, Christian; Jimenez-Solem, Espen.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 94, No. 6, 06.2015, p. 591-7.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Use of thyroid hormones in relation to pregnancy
T2 - a Danish nationwide cohort study
AU - Gidén, Karin
AU - Andersen, Jon Traerup
AU - Torp-Pedersen, Arendse Laerke
AU - Enghusen Poulsen, Henrik
AU - Torp-Pedersen, Christian
AU - Jimenez-Solem, Espen
N1 - © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2015/6
Y1 - 2015/6
N2 - OBJECTIVE: To determine the rate of exposure of pregnant women to levothyroxine and to assess changes in these rates before, during and after pregnancy.DESIGN: Register-based cohort study.SETTING: Danish nationwide registers.POPULATION: All women having a live birth in Denmark between 1 January 1997 and 31 December 2010 (n = 912 342).METHODS: All pregnant women in the study period were identified from the Danish Medical Birth Register. Exposed women were identified from the Danish National Prescription Register, based on redemption of levothyroxine prescriptions before, during or after pregnancy.MAIN OUTCOME MEASURES: The rate of pregnant women redeeming levothyroxine prescriptions and maternal characteristics.RESULTS: We identified a fourfold increase in levothyroxine prescription redemption during the study period, from 0.34% in 1997 to 1.39% by 2010. A mean of 0.79% of our cohort received levothyroxine. Most of the women who were using levothyroxine before pregnancy continued the therapy during their pregnancy, but 9.4% stopped redeeming their prescriptions. Overall, 0.28% of our cohort received a levothyroxine prescription for the first time within 9 months after pregnancy.CONCLUSIONS: Fewer women than expected received levothyroxine treatment during pregnancy even though a fourfold increase was observed during the study period. Furthermore, one of 10 discontinued treatments during pregnancy. These findings all indicate that too few women are treated for hypothyroidism during pregnancy. Further research is needed to determine whether hypothyroid pregnant women are suboptimally treated and the possible consequences for the mother and fetus.
AB - OBJECTIVE: To determine the rate of exposure of pregnant women to levothyroxine and to assess changes in these rates before, during and after pregnancy.DESIGN: Register-based cohort study.SETTING: Danish nationwide registers.POPULATION: All women having a live birth in Denmark between 1 January 1997 and 31 December 2010 (n = 912 342).METHODS: All pregnant women in the study period were identified from the Danish Medical Birth Register. Exposed women were identified from the Danish National Prescription Register, based on redemption of levothyroxine prescriptions before, during or after pregnancy.MAIN OUTCOME MEASURES: The rate of pregnant women redeeming levothyroxine prescriptions and maternal characteristics.RESULTS: We identified a fourfold increase in levothyroxine prescription redemption during the study period, from 0.34% in 1997 to 1.39% by 2010. A mean of 0.79% of our cohort received levothyroxine. Most of the women who were using levothyroxine before pregnancy continued the therapy during their pregnancy, but 9.4% stopped redeeming their prescriptions. Overall, 0.28% of our cohort received a levothyroxine prescription for the first time within 9 months after pregnancy.CONCLUSIONS: Fewer women than expected received levothyroxine treatment during pregnancy even though a fourfold increase was observed during the study period. Furthermore, one of 10 discontinued treatments during pregnancy. These findings all indicate that too few women are treated for hypothyroidism during pregnancy. Further research is needed to determine whether hypothyroid pregnant women are suboptimally treated and the possible consequences for the mother and fetus.
KW - Adult
KW - Denmark
KW - Female
KW - Humans
KW - Hypothyroidism
KW - Pregnancy
KW - Pregnancy Outcome
KW - Registries
KW - Thyroxine
U2 - 10.1111/aogs.12621
DO - 10.1111/aogs.12621
M3 - Journal article
C2 - 25732102
VL - 94
SP - 591
EP - 597
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 6
ER -
ID: 161661388