Use of antidepressants in women after prophylactic bilateral oophorectomy: A Danish national cohort study
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Use of antidepressants in women after prophylactic bilateral oophorectomy : A Danish national cohort study. / Abildgaard, Julie; Ahlström, Magnus Glindvad; Nielsen, Dorte Lisbeth; Daugaard, Gedske; Lindegaard, Birgitte; Obel, Niels; Lidegaard, Øjvind.
In: Psycho-Oncology, Vol. 29, No. 4, 2020, p. 655-662.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Use of antidepressants in women after prophylactic bilateral oophorectomy
T2 - A Danish national cohort study
AU - Abildgaard, Julie
AU - Ahlström, Magnus Glindvad
AU - Nielsen, Dorte Lisbeth
AU - Daugaard, Gedske
AU - Lindegaard, Birgitte
AU - Obel, Niels
AU - Lidegaard, Øjvind
N1 - © 2019 John Wiley & Sons, Ltd.
PY - 2020
Y1 - 2020
N2 - OBJECTIVE: To investigate the association between prophylactic bilateral oophorectomy and use of antidepressants in women with a family history of cancer.METHODS: Nationwide population-based cohort study using Danish National Registries including women oophorectomized due to a family history of cancer (n = 2,002) and an age matched reference group (n = 18,018). Analyses were stratified by age at time of bilateral oophorectomy and use of hormone replacement therapy (HRT).RESULTS: Women oophorectomized at age ≤ 45 years were more likely to use antidepressants from the first year after bilateral oophorectomy (OR = 1.34; 95 % CI: 1.08-1.65) compared to the reference group. Women oophorectomized at age 46-55 years and at age >55 years had no significantly increased use of antidepressants (OR = 0.90; 95 % CI: 0.68-1.18 and OR = 1.14; 95 % CI: 0.81-1.61). The increased use of antidepressants in women oophorectomized at age ≤ 45 years was limited to women treated with HRT (OR = 1.51; 95 % CI: 1.18-1.94) whereas women oophorectomized at age ≤ 45 years not treated with HRT had no increased use of antidepressants (OR = 1.03; 95 % CI: 0.70-1.51).CONCLUSIONS: Women oophorectomized due to a family history of cancer at age ≤ 45 years were more likely to use antidepressants after bilateral oophorectomy. The increased use of antidepressants was limited to women treated with HRT. The study calls for further large-scale studies to understand how bilateral oophorectomy and concomitant HRT affects risk of depression in women with a family history of cancer.
AB - OBJECTIVE: To investigate the association between prophylactic bilateral oophorectomy and use of antidepressants in women with a family history of cancer.METHODS: Nationwide population-based cohort study using Danish National Registries including women oophorectomized due to a family history of cancer (n = 2,002) and an age matched reference group (n = 18,018). Analyses were stratified by age at time of bilateral oophorectomy and use of hormone replacement therapy (HRT).RESULTS: Women oophorectomized at age ≤ 45 years were more likely to use antidepressants from the first year after bilateral oophorectomy (OR = 1.34; 95 % CI: 1.08-1.65) compared to the reference group. Women oophorectomized at age 46-55 years and at age >55 years had no significantly increased use of antidepressants (OR = 0.90; 95 % CI: 0.68-1.18 and OR = 1.14; 95 % CI: 0.81-1.61). The increased use of antidepressants in women oophorectomized at age ≤ 45 years was limited to women treated with HRT (OR = 1.51; 95 % CI: 1.18-1.94) whereas women oophorectomized at age ≤ 45 years not treated with HRT had no increased use of antidepressants (OR = 1.03; 95 % CI: 0.70-1.51).CONCLUSIONS: Women oophorectomized due to a family history of cancer at age ≤ 45 years were more likely to use antidepressants after bilateral oophorectomy. The increased use of antidepressants was limited to women treated with HRT. The study calls for further large-scale studies to understand how bilateral oophorectomy and concomitant HRT affects risk of depression in women with a family history of cancer.
U2 - 10.1002/pon.5290
DO - 10.1002/pon.5290
M3 - Journal article
C2 - 31733110
VL - 29
SP - 655
EP - 662
JO - Psycho-Oncology
JF - Psycho-Oncology
SN - 1057-9249
IS - 4
ER -
ID: 236015466