Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol
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This paper presents the work performed to transition a lab-scale synthesis (1 g) to a large-scale (400 g) synthesis of the 3-5-diamino-1H-Pyrazole Disperazol, a new pharmaceutical for treatment of antibiotic-resistant Pseudomonas aeruginosa biofilm infections. The potentially hazardous diazotisation step in the lab-scale synthesis was transformed to a safe and easy-to-handle flow chemistry step. Additionally, the paper presents an OSHA-recommended safety assessment of active compound E, as performed by Fauske and Associates, LLC, Burr Ridge, IL, USA.
Original language | English |
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Article number | 6737 |
Journal | International Journal of Molecular Sciences |
Volume | 25 |
Issue number | 12 |
Number of pages | 8 |
ISSN | 1661-6596 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Publisher Copyright:
© 2024 by the authors.
- biofilm, c-di-GMP, dispersal, dust analysis, flow chemistry, large-scale synthesis, preclinical, Pseudomonas aeruginosa, pyrazole, safety
Research areas
ID: 398072077