TY - JOUR

T1 - Unsolicited information letters to increase awareness of Lynch syndrome and familial colorectal cancer

T2 - reactions and attitudes

AU - Petersen, Helle Vendel

AU - Frederiksen, Birgitte Lidegaard

AU - Lautrup, Charlotte Kvist

AU - Lindberg, Lars Joachim

AU - Ladelund, Steen

AU - Nilbert, Mef

PY - 2019

Y1 - 2019

N2 - Dissemination of information on a genetically increased risk should according to guidelines primarily be family-mediated. Incomplete and incorrect information spread has, however, been documented and implies missed possibilities for prevention. In Denmark, the national HNPCC register has been granted an exception to send unsolicited letters with information on hereditary colorectal cancer and an invitation to genetic counseling to members of families with familial and hereditary colorectal cancer. To evaluate this approach, we investigated reactions and attitudes to unsolicited letters in 708 members of families with genetic predisposition and in 1600 individuals from the general population. Support for information letters was expressed by 78% of the family members and by 82% of the general population. Regarding route of information, 90% of family members preferred a letter to no information, 66% preferred information from the hospital rather than from family members and 40% preferred to obtain information from a close family member. Our results suggest that use of unsolicited information letters from the health care system may be a feasible and highly acceptable strategy to disseminate information to families at high risk of colorectal cancer.

AB - Dissemination of information on a genetically increased risk should according to guidelines primarily be family-mediated. Incomplete and incorrect information spread has, however, been documented and implies missed possibilities for prevention. In Denmark, the national HNPCC register has been granted an exception to send unsolicited letters with information on hereditary colorectal cancer and an invitation to genetic counseling to members of families with familial and hereditary colorectal cancer. To evaluate this approach, we investigated reactions and attitudes to unsolicited letters in 708 members of families with genetic predisposition and in 1600 individuals from the general population. Support for information letters was expressed by 78% of the family members and by 82% of the general population. Regarding route of information, 90% of family members preferred a letter to no information, 66% preferred information from the hospital rather than from family members and 40% preferred to obtain information from a close family member. Our results suggest that use of unsolicited information letters from the health care system may be a feasible and highly acceptable strategy to disseminate information to families at high risk of colorectal cancer.

KW - Attitudes towards unsolicited risk information

KW - Direct approach

KW - Dissemination of genetic information

KW - Hereditary colorectal cancer

KW - Reactions to risk information

U2 - 10.1007/s10689-018-0083-5

DO - 10.1007/s10689-018-0083-5

M3 - Journal article

C2 - 29651783

AN - SCOPUS:85045273180

VL - 18

SP - 43

EP - 51

JO - Familial Cancer

JF - Familial Cancer

SN - 1389-9600

IS - 1

ER -