Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
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Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. / Osmark, P; Hansson, O; Jonsson, Anna Elisabet; Rönn, T; Groop, L; Renström, E.
In: Diabetologia, Vol. 52, No. 5, 05.2009, p. 850-4.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
AU - Osmark, P
AU - Hansson, O
AU - Jonsson, Anna Elisabet
AU - Rönn, T
AU - Groop, L
AU - Renström, E
PY - 2009/5
Y1 - 2009/5
N2 - Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.
AB - Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.
KW - Adipose Tissue
KW - Adult
KW - Aged
KW - Alternative Splicing
KW - Cadaver
KW - Diabetes Mellitus, Type 2
KW - Exons
KW - Female
KW - Genetic Variation
KW - Humans
KW - Islets of Langerhans
KW - Lymphocytes
KW - Male
KW - Middle Aged
KW - Muscle, Skeletal
KW - RNA
KW - Reference Values
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - TCF Transcription Factors
KW - Tissue Donors
KW - Transcription Factor 7-Like 2 Protein
KW - Transcription, Genetic
U2 - 10.1007/s00125-009-1293-z
DO - 10.1007/s00125-009-1293-z
M3 - Journal article
C2 - 19247628
VL - 52
SP - 850
EP - 854
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 5
ER -
ID: 46404471