Types I and III procollagen extension peptides in serum respond to fracture in humans
Research output: Contribution to journal › Journal article › Research › peer-review
Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations between the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.
Original language | English |
---|---|
Journal | Archives of Orthopaedic and Trauma Surgery |
Volume | 111 |
Issue number | 5 |
Pages (from-to) | 265-7 |
Number of pages | 3 |
ISSN | 0936-8051 |
DOIs | |
Publication status | Published - 1992 |
Externally published | Yes |
- Adult, Aged, Aged, 80 and over, Colles' Fracture, Female, Humans, Male, Middle Aged, Osteocalcin, Peptide Fragments, Procollagen, Journal Article, Research Support, Non-U.S. Gov't
Research areas
ID: 168533374