Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints
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Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints. / Torstensen, Eva Wiberg; Brinth, Louise Schouborg; Mehlsen, Jesper; Kornum, Birgitte Rahbek; Jennum, Poul Jørgensen.
In: Danish Medical Journal, Vol. 65, No. 11, A5510, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints
AU - Torstensen, Eva Wiberg
AU - Brinth, Louise Schouborg
AU - Mehlsen, Jesper
AU - Kornum, Birgitte Rahbek
AU - Jennum, Poul Jørgensen
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2018
Y1 - 2018
N2 - INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.FUNDING: none.TRIAL REGISTRATION: not relevant.
AB - INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.FUNDING: none.TRIAL REGISTRATION: not relevant.
KW - Adolescent
KW - Adult
KW - Child
KW - Denmark/epidemiology
KW - Female
KW - Humans
KW - Narcolepsy/epidemiology
KW - Orexins/cerebrospinal fluid
KW - Papillomavirus Vaccines/adverse effects
KW - Polysomnography
KW - Retrospective Studies
KW - Sleep
KW - Young Adult
M3 - Journal article
C2 - 30382019
VL - 65
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 11
M1 - A5510
ER -
ID: 217565504