TY - JOUR

T1 - Two-year fixation and ten-year clinical outcomes of total knee arthroplasty inserted with normal-curing bone cement and slow-curing bone cement

T2 - A randomized controlled trial in 54 patients

AU - Breddam Mosegaard, Sebastian

AU - Rytter, Søren

AU - Madsen, Frank

AU - Odgaard, Anders

AU - Søballe, Kjeld

AU - Stilling, Maiken

N1 - Publisher Copyright: © 2021 The Authors

PY - 2021/12

Y1 - 2021/12

N2 - Background: The normal-curing Refobacin® Bone Cement R (RR) and slow-curing Refobacin® Plus Bone Cement (RP) were introduced after discontinuation of the historically most used bone cement, Refobacin®-Palacos® R, in 2005. The aim of this study was to compare total knee arthroplasty component fixation with the two bone cements. Methods: 54 patients with primary knee osteoarthritis were randomized to either RR (N = 27) or RP (N = 27) bone cement and followed for two years with radiostereometric analysis of tibial and femoral component migration and dual-energy x-ray absorptiometry measured periprosthetic bone mineral density (BMD). Further, patients were followed up at ten years with clinical outcome scores (OKS and KOOS). Results: At two-years follow-up, tibial total translation was 0.31 mm (95% CI: 0.19 – 0.42) for the RP group and 0.56 mm (95% CI: 0.45 – 0.67) (p < 0.01) for the RR group. There was continuous tibial component migration from one to two years follow-up (MTPM > 0.2 mm) in 13/27 patients from the RR and in 12/26 patients from the RP group. There was no difference between groups in BMD baseline values or changes during follow-up, as well as no correlation between change in BMD and tibial component migration. At ten-years follow-up, the improvement in the clinical outcome scores was similar between groups. There were no prosthesis related complications during the 10-year follow-up. Conclusion: At two years, tibial total translation was lower in the RP compared with the RR cement group, but BMD changes were similar. At ten years, no components were revised and clinical outcome scores were similar between groups.

AB - Background: The normal-curing Refobacin® Bone Cement R (RR) and slow-curing Refobacin® Plus Bone Cement (RP) were introduced after discontinuation of the historically most used bone cement, Refobacin®-Palacos® R, in 2005. The aim of this study was to compare total knee arthroplasty component fixation with the two bone cements. Methods: 54 patients with primary knee osteoarthritis were randomized to either RR (N = 27) or RP (N = 27) bone cement and followed for two years with radiostereometric analysis of tibial and femoral component migration and dual-energy x-ray absorptiometry measured periprosthetic bone mineral density (BMD). Further, patients were followed up at ten years with clinical outcome scores (OKS and KOOS). Results: At two-years follow-up, tibial total translation was 0.31 mm (95% CI: 0.19 – 0.42) for the RP group and 0.56 mm (95% CI: 0.45 – 0.67) (p < 0.01) for the RR group. There was continuous tibial component migration from one to two years follow-up (MTPM > 0.2 mm) in 13/27 patients from the RR and in 12/26 patients from the RP group. There was no difference between groups in BMD baseline values or changes during follow-up, as well as no correlation between change in BMD and tibial component migration. At ten-years follow-up, the improvement in the clinical outcome scores was similar between groups. There were no prosthesis related complications during the 10-year follow-up. Conclusion: At two years, tibial total translation was lower in the RP compared with the RR cement group, but BMD changes were similar. At ten years, no components were revised and clinical outcome scores were similar between groups.

KW - BMD

KW - Bone Cement

KW - Knee

KW - RSA

KW - Total Knee Arthroplasty

U2 - 10.1016/j.knee.2021.08.027

DO - 10.1016/j.knee.2021.08.027

M3 - Journal article

C2 - 34619515

AN - SCOPUS:85116373460

VL - 33

SP - 110

EP - 124

JO - Knee

JF - Knee

SN - 0968-0160

ER -