Travel light: Essential packing for membrane proteins with an active lifestyle
Research output: Contribution to journal › Review › Research › peer-review
Standard
Travel light : Essential packing for membrane proteins with an active lifestyle. / Johansen, Nicolai Tidemand; Tidemand, Frederik Grønbæk; Pedersen, Martin Cramer; Arleth, Lise.
In: Biochimie, Vol. 205, 2023, p. 3-26.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Travel light
T2 - Essential packing for membrane proteins with an active lifestyle
AU - Johansen, Nicolai Tidemand
AU - Tidemand, Frederik Grønbæk
AU - Pedersen, Martin Cramer
AU - Arleth, Lise
N1 - Publisher Copyright: © 2022 The Authors
PY - 2023
Y1 - 2023
N2 - We review the considerable progress during the recent decade in the endeavours of designing, optimising, and utilising carrier particle systems for structural and functional studies of membrane proteins in near-native environments. New and improved systems are constantly emerging, novel studies push the perceived limits of a given carrier system, and specific carrier systems consolidate and entrench themselves as the system of choice for particular classes of target membrane protein systems. This review covers the most frequently used carrier systems for such studies and emphasises similarities and differences between these systems as well as current trends and future directions for the field. Particular interest is devoted to the biophysical properties and membrane mimicking ability of each system and the manner in which this may impact an embedded membrane protein and an eventual structural or functional study.
AB - We review the considerable progress during the recent decade in the endeavours of designing, optimising, and utilising carrier particle systems for structural and functional studies of membrane proteins in near-native environments. New and improved systems are constantly emerging, novel studies push the perceived limits of a given carrier system, and specific carrier systems consolidate and entrench themselves as the system of choice for particular classes of target membrane protein systems. This review covers the most frequently used carrier systems for such studies and emphasises similarities and differences between these systems as well as current trends and future directions for the field. Particular interest is devoted to the biophysical properties and membrane mimicking ability of each system and the manner in which this may impact an embedded membrane protein and an eventual structural or functional study.
KW - Amphiphilic polymers
KW - Carrier system
KW - Membrane protein
KW - Micelle
KW - Nanodisc
U2 - 10.1016/j.biochi.2022.07.014
DO - 10.1016/j.biochi.2022.07.014
M3 - Review
C2 - 35963461
AN - SCOPUS:85136266700
VL - 205
SP - 3
EP - 26
JO - Biochimie
JF - Biochimie
SN - 0300-9084
ER -
ID: 339633955