Transfer of bromocriptine across the blood-brain barrier in man
Research output: Contribution to journal › Journal article › Research › peer-review
The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration. Its T 1/2 was found to be 12--24 minutes, depending on the tissue-blood partition coefficient.
| Original language | English |
|---|---|
| Book series | Acta Neurologica Scandinavica |
| Volume | 59 |
| Issue number | 2-3 |
| Pages (from-to) | 88-95 |
| Number of pages | 8 |
| ISSN | 0001-6314 |
| DOIs | |
| Publication status | Published - Mar 1979 |
- Adult, Aged, Blood-Brain Barrier, Brain/metabolism, Brain Diseases/drug therapy, Bromocriptine/blood, Carbon Radioisotopes, Cerebrovascular Circulation, Female, Humans, Male, Middle Aged, Radioisotope Dilution Technique, Time Factors
Research areas
ID: 275605354