T(peak)T(end) interval in long QT syndrome
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T(peak)T(end) interval in long QT syndrome. / Kanters, Jørgen Kim; Haarmark, Christian; Vedel-Larsen, Esben; Andersen, Mads P; Graff, Claus; Struijk, Johannes J; Thomsen, Poul Erik Bloch; Christiansen, Michael; Jensen, Henrik K; Toft, Egon.
In: Journal of Electrocardiology, Vol. 41, No. 6, 2008, p. 603-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - T(peak)T(end) interval in long QT syndrome
AU - Kanters, Jørgen Kim
AU - Haarmark, Christian
AU - Vedel-Larsen, Esben
AU - Andersen, Mads P
AU - Graff, Claus
AU - Struijk, Johannes J
AU - Thomsen, Poul Erik Bloch
AU - Christiansen, Michael
AU - Jensen, Henrik K
AU - Toft, Egon
N1 - Keywords: Adult; Comorbidity; Denmark; Diagnosis, Computer-Assisted; Electrocardiography; Female; Humans; Incidence; Long QT Syndrome; Male; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Syncope
PY - 2008
Y1 - 2008
N2 - BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. METHODS: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. RESULTS AND CONCLUSION: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.
AB - BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. METHODS: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. RESULTS AND CONCLUSION: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.
U2 - 10.1016/j.jelectrocard.2008.07.024
DO - 10.1016/j.jelectrocard.2008.07.024
M3 - Journal article
C2 - 18822425
VL - 41
SP - 603
EP - 608
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
SN - 0022-0736
IS - 6
ER -
ID: 19793047