Towards a standardized bioinformatics infrastructure for N- and O-glycomics
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- Towards a standardized bioinformatics infrastructure for N- and O-glycomics
Final published version, 1.07 MB, PDF document
The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N- and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This workflow enables the standardized submission of MS-based glycomics information into the public repository UniCarb-DR. It implements the MIRAGE (Minimum Requirement for A Glycomics Experiment) reporting guidelines, storage of unprocessed MS data in the GlycoPOST repository and glycan structure registration using the GlyTouCan registry, thereby supporting the development and extension of a glycan structure knowledgebase.
Original language | English |
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Article number | 3275 |
Journal | Nature Communications |
Volume | 10 |
Issue number | 1 |
Number of pages | 10 |
ISSN | 2041-1723 |
DOIs | |
Publication status | Published - 2019 |
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