Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition
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Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition. / Rimbach, Rebecca; Yamada, Yosuke; Sagayama, Hiroyuki; Sjödin, Anders Mikael; Luke, Amy H; Rood, Jennifer; Schoeller, Dale R; Westerterp, Klaas R; Wong, William W; Speakman, John R; Pontzer, Herman; IAEA DLW Database Consortium.
In: Nature Communications, Vol. 13, 99, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition
AU - Rimbach, Rebecca
AU - Yamada, Yosuke
AU - Sagayama, Hiroyuki
AU - Ainslie, Philip N
AU - Anderson, Lene F
AU - Anderson, Liam J
AU - Arab, Lenore
AU - Baddou, Issaad
AU - Bedu-Addo, Kweku
AU - Blaak, Ellen E
AU - Blanc, Stephane
AU - Bonomi, Alberto G
AU - Bouten, Carlijn V C
AU - Bovet, Pascal
AU - Buchowski, Maciej S
AU - Butte, Nancy F
AU - Camps, Stefan G J A
AU - Close, Graeme L
AU - Cooper, Jamie A
AU - Das, Sai Krupa
AU - Dugas, Lara R
AU - Ekelund, Ulf
AU - Entringer, Sonja
AU - Forrester, Terrence
AU - Fudge, Barry W
AU - Goris, Annelies H
AU - Gurven, Michael
AU - Hambly, Catherine
AU - El Hamdouchi, Asmaa
AU - Hoos, Marije B
AU - Hu, Sumei
AU - Joonas, Noorjehan
AU - Joosen, Annemiek M
AU - Katzmarzyk, Peter
AU - Kempen, Kitty P
AU - Kimura, Misaka
AU - Kraus, William E
AU - Kushner, Robert F
AU - Lambert, Estelle V
AU - Leonard, William R
AU - Lessan, Nader
AU - Martin, Corby K
AU - Medin, Anine C
AU - Meijer, Erwin P
AU - Morehen, James C
AU - Morton, James P
AU - Neuhouser, Marian L
AU - Nicklas, Theresa A
AU - Sjödin, Anders Mikael
AU - Wood, Brian M
AU - Luke, Amy H
AU - Rood, Jennifer
AU - Schoeller, Dale R
AU - Westerterp, Klaas R
AU - Wong, William W
AU - Speakman, John R
AU - Pontzer, Herman
AU - IAEA DLW Database Consortium
N1 - © 2022. The Author(s).
PY - 2022
Y1 - 2022
N2 - Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.
AB - Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.
KW - Adipose Tissue/metabolism
KW - Adult
KW - Bayes Theorem
KW - Body Composition/physiology
KW - Child
KW - Databases, Factual
KW - Energy Metabolism/physiology
KW - Female
KW - Humans
KW - Isotope Labeling
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Water/metabolism
KW - Weight Gain/physiology
U2 - 10.1038/s41467-021-27246-z
DO - 10.1038/s41467-021-27246-z
M3 - Journal article
C2 - 35013190
VL - 13
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 99
ER -
ID: 291013322