Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe
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Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe. / Rodriguez Martin, Laura; Gilles, Liese; Helte, Emilie; Åkesson, Agneta; Tägt, Jonas; Covaci, Adrian; Sakhi, Amrit K.; Van Nieuwenhuyse, An; Katsonouri, Andromachi; Andersson, Anna Maria; Gutleb, Arno C.; Janasik, Beata; Appenzeller, Brice; Gabriel, Catherine; Thomsen, Cathrine; Mazej, Darja; Sarigiannis, Denis; Anastasi, Elena; Barbone, Fabio; Tolonen, Hanna; Frederiksen, Hanne; Klanova, Jana; Koponen, Jani; Tratnik, Janja Snoj; Pack, Kim; Gudrun, Koppen; Ólafsdóttir, Kristin; Knudsen, Lisbeth E.; Rambaud, Loïc; Strumylaite, Loreta; Murinova, Lubica Palkovicova; Fabelova, Lucia; Riou, Margaux; Berglund, Marika; Szabados, Maté; Imboden, Medea; Laeremans, Michelle; Eštóková, Milada; Janev Holcer, Natasa; Probst-Hensch, Nicole; Vodrazkova, Nicole; Vogel, Nina; Piler, Pavel; Schmidt, Phillipp; Lange, Rosa; Namorado, Sónia; Kozepesy, Szilvia; Szigeti, Tamás; Halldorsson, Thorhallur I.; Weber, Till; Jensen, Tina Kold; Rosolen, Valentina; Puklova, Vladimira; Wasowicz, Wojciech; Sepai, Ovnair; Stewart, Lorraine; Kolossa-Gehring, Marike; Esteban-López, Marta; Castaño, Argelia; Bessems, Jos; Schoeters, Greet; Govarts, Eva.
In: Toxics, Vol. 11, No. 10, 819, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe
AU - Rodriguez Martin, Laura
AU - Gilles, Liese
AU - Helte, Emilie
AU - Åkesson, Agneta
AU - Tägt, Jonas
AU - Covaci, Adrian
AU - Sakhi, Amrit K.
AU - Van Nieuwenhuyse, An
AU - Katsonouri, Andromachi
AU - Andersson, Anna Maria
AU - Gutleb, Arno C.
AU - Janasik, Beata
AU - Appenzeller, Brice
AU - Gabriel, Catherine
AU - Thomsen, Cathrine
AU - Mazej, Darja
AU - Sarigiannis, Denis
AU - Anastasi, Elena
AU - Barbone, Fabio
AU - Tolonen, Hanna
AU - Frederiksen, Hanne
AU - Klanova, Jana
AU - Koponen, Jani
AU - Tratnik, Janja Snoj
AU - Pack, Kim
AU - Gudrun, Koppen
AU - Ólafsdóttir, Kristin
AU - Knudsen, Lisbeth E.
AU - Rambaud, Loïc
AU - Strumylaite, Loreta
AU - Murinova, Lubica Palkovicova
AU - Fabelova, Lucia
AU - Riou, Margaux
AU - Berglund, Marika
AU - Szabados, Maté
AU - Imboden, Medea
AU - Laeremans, Michelle
AU - Eštóková, Milada
AU - Janev Holcer, Natasa
AU - Probst-Hensch, Nicole
AU - Vodrazkova, Nicole
AU - Vogel, Nina
AU - Piler, Pavel
AU - Schmidt, Phillipp
AU - Lange, Rosa
AU - Namorado, Sónia
AU - Kozepesy, Szilvia
AU - Szigeti, Tamás
AU - Halldorsson, Thorhallur I.
AU - Weber, Till
AU - Jensen, Tina Kold
AU - Rosolen, Valentina
AU - Puklova, Vladimira
AU - Wasowicz, Wojciech
AU - Sepai, Ovnair
AU - Stewart, Lorraine
AU - Kolossa-Gehring, Marike
AU - Esteban-López, Marta
AU - Castaño, Argelia
AU - Bessems, Jos
AU - Schoeters, Greet
AU - Govarts, Eva
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. For 2014–2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5–12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24–52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM.
AB - Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. For 2014–2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5–12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24–52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM.
KW - bisphenols
KW - cadmium
KW - DINCH
KW - hazardous chemical
KW - human biomonitoring
KW - OPFRs
KW - PAHs
KW - phthalates
U2 - 10.3390/toxics11100819
DO - 10.3390/toxics11100819
M3 - Journal article
C2 - 37888670
AN - SCOPUS:85175447527
VL - 11
JO - Toxics
JF - Toxics
SN - 2305-6304
IS - 10
M1 - 819
ER -
ID: 374305496