Thromboembolic Complications in Fontan Patients: Population-Based Prevalence and Exploration of the Etiology

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Thromboembolic Complications in Fontan Patients : Population-Based Prevalence and Exploration of the Etiology. / Idorn, L; Jensen, A S; Juul, K; Reimers, J.I.; Johansson, P I; Sørensen, K E; Ostrowski, S R; Søndergaard, L.

In: Annals of Pediatric Cardiology, Vol. 34, No. 2, 2013, p. 262-72.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Idorn, L, Jensen, AS, Juul, K, Reimers, JI, Johansson, PI, Sørensen, KE, Ostrowski, SR & Søndergaard, L 2013, 'Thromboembolic Complications in Fontan Patients: Population-Based Prevalence and Exploration of the Etiology', Annals of Pediatric Cardiology, vol. 34, no. 2, pp. 262-72. https://doi.org/10.1007/s00246-012-0431-4

APA

Idorn, L., Jensen, A. S., Juul, K., Reimers, J. I., Johansson, P. I., Sørensen, K. E., Ostrowski, S. R., & Søndergaard, L. (2013). Thromboembolic Complications in Fontan Patients: Population-Based Prevalence and Exploration of the Etiology. Annals of Pediatric Cardiology, 34(2), 262-72. https://doi.org/10.1007/s00246-012-0431-4

Vancouver

Idorn L, Jensen AS, Juul K, Reimers JI, Johansson PI, Sørensen KE et al. Thromboembolic Complications in Fontan Patients: Population-Based Prevalence and Exploration of the Etiology. Annals of Pediatric Cardiology. 2013;34(2):262-72. https://doi.org/10.1007/s00246-012-0431-4

Author

Idorn, L ; Jensen, A S ; Juul, K ; Reimers, J.I. ; Johansson, P I ; Sørensen, K E ; Ostrowski, S R ; Søndergaard, L. / Thromboembolic Complications in Fontan Patients : Population-Based Prevalence and Exploration of the Etiology. In: Annals of Pediatric Cardiology. 2013 ; Vol. 34, No. 2. pp. 262-72.

Bibtex

@article{96b57f0cf6c04a42bb9e6b13e25b95c0,
title = "Thromboembolic Complications in Fontan Patients: Population-Based Prevalence and Exploration of the Etiology",
abstract = "After the Fontan procedure, patients face an increased risk for thromboembolic events (TE). The etiology for this increased thrombogenecity is incompletely understood. This study aimed to determine the prevalence of TE in Danish Fontan patients and to bring new insights into the etiology of TE. Using a population-based design, we retrospectively identified all TEs in 210 Fontan patients. Whole blood assays (thromboelastography, thromboelastography functional fibrinogen and Multiplate) reflecting global hemostasis, clot strength and platelet aggregation were analyzed prospectively in 112 patients and plasma was analyzed in 76 patients for biomarkers reflecting endothelial-, glycocalyx-, platelet-, and fibrinolysis function (histone-complexed DNA fragments, Protein C, soluble CD40 ligand, soluble thrombomodulin, syndecan-1, tissue-type plasminogen activator). The results were compared in groups stratified according to age, antithrombotic therapy, TE, and glycocalyx degradation (syndecan-1 ",
author = "L Idorn and Jensen, {A S} and K Juul and J.I. Reimers and Johansson, {P I} and S{\o}rensen, {K E} and Ostrowski, {S R} and L S{\o}ndergaard",
year = "2013",
doi = "10.1007/s00246-012-0431-4",
language = "English",
volume = "34",
pages = "262--72",
journal = "Annals of Pediatric Cardiology",
issn = "0974-2069",
publisher = "Medknow Publications and Media Pvt. Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Thromboembolic Complications in Fontan Patients

T2 - Population-Based Prevalence and Exploration of the Etiology

AU - Idorn, L

AU - Jensen, A S

AU - Juul, K

AU - Reimers, J.I.

AU - Johansson, P I

AU - Sørensen, K E

AU - Ostrowski, S R

AU - Søndergaard, L

PY - 2013

Y1 - 2013

N2 - After the Fontan procedure, patients face an increased risk for thromboembolic events (TE). The etiology for this increased thrombogenecity is incompletely understood. This study aimed to determine the prevalence of TE in Danish Fontan patients and to bring new insights into the etiology of TE. Using a population-based design, we retrospectively identified all TEs in 210 Fontan patients. Whole blood assays (thromboelastography, thromboelastography functional fibrinogen and Multiplate) reflecting global hemostasis, clot strength and platelet aggregation were analyzed prospectively in 112 patients and plasma was analyzed in 76 patients for biomarkers reflecting endothelial-, glycocalyx-, platelet-, and fibrinolysis function (histone-complexed DNA fragments, Protein C, soluble CD40 ligand, soluble thrombomodulin, syndecan-1, tissue-type plasminogen activator). The results were compared in groups stratified according to age, antithrombotic therapy, TE, and glycocalyx degradation (syndecan-1 

AB - After the Fontan procedure, patients face an increased risk for thromboembolic events (TE). The etiology for this increased thrombogenecity is incompletely understood. This study aimed to determine the prevalence of TE in Danish Fontan patients and to bring new insights into the etiology of TE. Using a population-based design, we retrospectively identified all TEs in 210 Fontan patients. Whole blood assays (thromboelastography, thromboelastography functional fibrinogen and Multiplate) reflecting global hemostasis, clot strength and platelet aggregation were analyzed prospectively in 112 patients and plasma was analyzed in 76 patients for biomarkers reflecting endothelial-, glycocalyx-, platelet-, and fibrinolysis function (histone-complexed DNA fragments, Protein C, soluble CD40 ligand, soluble thrombomodulin, syndecan-1, tissue-type plasminogen activator). The results were compared in groups stratified according to age, antithrombotic therapy, TE, and glycocalyx degradation (syndecan-1 

U2 - 10.1007/s00246-012-0431-4

DO - 10.1007/s00246-012-0431-4

M3 - Journal article

C2 - 22843202

VL - 34

SP - 262

EP - 272

JO - Annals of Pediatric Cardiology

JF - Annals of Pediatric Cardiology

SN - 0974-2069

IS - 2

ER -

ID: 48549164