Thermodynamics of proteins: Fast folders and sharp transitions
Research output: Contribution to journal › Journal article › Research › peer-review
Several small globular proteins exhibit a simple two-state folding process (sharp transition). The rather short folding times of proteins (fast folders) indicate that folding is guided through some sequence of contact bindings. We discuss the possibility for reconciling a two-state folding event with a sequential folding process, i.e. a folding pathway in a schematic model of protein folding. We show that both single and multiple folding pathways can lead to an apparent two-state folding from a thermodynamic point of view. We also discuss water interactions in protein folding, leading to cold and warm destabilization of the protein.
Original language | English |
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Journal | Computer Physics Communications |
Volume | 147 |
Issue number | 1-2 |
Pages (from-to) | 307-312 |
Number of pages | 6 |
ISSN | 0010-4655 |
DOIs | |
Publication status | Published - 1 Jan 2002 |
- Folding pathway, Protein folding, Thermodynamics, Van't Hoff enthalpy relation
Research areas
ID: 217103908