Thermodynamics of proteins: Fast folders and sharp transitions
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Thermodynamics of proteins : Fast folders and sharp transitions. / Bakk, Audun; Dommersnes, Paul G.; Hansen, Alex; Høye, Johan S.; Sneppen, Kim; Jensen, Mogens H.
In: Computer Physics Communications, Vol. 147, No. 1-2, 01.01.2002, p. 307-312.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Thermodynamics of proteins
T2 - Fast folders and sharp transitions
AU - Bakk, Audun
AU - Dommersnes, Paul G.
AU - Hansen, Alex
AU - Høye, Johan S.
AU - Sneppen, Kim
AU - Jensen, Mogens H.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Several small globular proteins exhibit a simple two-state folding process (sharp transition). The rather short folding times of proteins (fast folders) indicate that folding is guided through some sequence of contact bindings. We discuss the possibility for reconciling a two-state folding event with a sequential folding process, i.e. a folding pathway in a schematic model of protein folding. We show that both single and multiple folding pathways can lead to an apparent two-state folding from a thermodynamic point of view. We also discuss water interactions in protein folding, leading to cold and warm destabilization of the protein.
AB - Several small globular proteins exhibit a simple two-state folding process (sharp transition). The rather short folding times of proteins (fast folders) indicate that folding is guided through some sequence of contact bindings. We discuss the possibility for reconciling a two-state folding event with a sequential folding process, i.e. a folding pathway in a schematic model of protein folding. We show that both single and multiple folding pathways can lead to an apparent two-state folding from a thermodynamic point of view. We also discuss water interactions in protein folding, leading to cold and warm destabilization of the protein.
KW - Folding pathway
KW - Protein folding
KW - Thermodynamics
KW - Van't Hoff enthalpy relation
UR - http://www.scopus.com/inward/record.url?scp=0036681493&partnerID=8YFLogxK
U2 - 10.1016/S0010-4655(02)00293-X
DO - 10.1016/S0010-4655(02)00293-X
M3 - Journal article
AN - SCOPUS:0036681493
VL - 147
SP - 307
EP - 312
JO - Computer Physics Communications
JF - Computer Physics Communications
SN - 0010-4655
IS - 1-2
ER -
ID: 217103908