The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- 1-s2.0-S2211124720308305-main
Final published version, 3.37 MB, PDF document
DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.
Original language | English |
---|---|
Article number | 107849 |
Journal | Cell Reports |
Volume | 32 |
Issue number | 1 |
Number of pages | 25 |
ISSN | 2211-1247 |
DOIs | |
Publication status | Published - 2020 |
- D-loop dissociation, DNA helicase, FANCD2, FANCJ, FANCM, Fanconi anemia, homologous recombination, interstrand DNA crosslink repair, RAD51, sister-chromatid exchange
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
No data available
ID: 244611396