The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection. / Cunha-Bang, C da; Kirkby, N; Sønderholm, M; Sørensen, S S; Sengeløv, H; Iversen, M; Rasmussen, A; Gustafsson, F; Frederiksen, C M; Kjaer, J; Lepri, A Cozzi; Lundgren, J D.

In: American Journal of Transplantation (Online), Vol. 13, No. 2, 02.2013, p. 458-66.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cunha-Bang, CD, Kirkby, N, Sønderholm, M, Sørensen, SS, Sengeløv, H, Iversen, M, Rasmussen, A, Gustafsson, F, Frederiksen, CM, Kjaer, J, Lepri, AC & Lundgren, JD 2013, 'The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection', American Journal of Transplantation (Online), vol. 13, no. 2, pp. 458-66. https://doi.org/10.1111/ajt.12042

APA

Cunha-Bang, C. D., Kirkby, N., Sønderholm, M., Sørensen, S. S., Sengeløv, H., Iversen, M., Rasmussen, A., Gustafsson, F., Frederiksen, C. M., Kjaer, J., Lepri, A. C., & Lundgren, J. D. (2013). The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection. American Journal of Transplantation (Online), 13(2), 458-66. https://doi.org/10.1111/ajt.12042

Vancouver

Cunha-Bang CD, Kirkby N, Sønderholm M, Sørensen SS, Sengeløv H, Iversen M et al. The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection. American Journal of Transplantation (Online). 2013 Feb;13(2):458-66. https://doi.org/10.1111/ajt.12042

Author

Cunha-Bang, C da ; Kirkby, N ; Sønderholm, M ; Sørensen, S S ; Sengeløv, H ; Iversen, M ; Rasmussen, A ; Gustafsson, F ; Frederiksen, C M ; Kjaer, J ; Lepri, A Cozzi ; Lundgren, J D. / The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection. In: American Journal of Transplantation (Online). 2013 ; Vol. 13, No. 2. pp. 458-66.

Bibtex

@article{036923df5a3342c3a0077922e5ed038c,
title = "The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection",
abstract = "(Val)ganciclovir is used to treat cytomegalovirus (CMV) infection following solid organ (SOT) or hematopoietic stem cell (HSCT) transplantation. Treatment failures occur, but the contribution from 39 known ganciclovir-related mutations (GRMs) in the CMV-UL97 gene remains controversial. We propose a categorization of these GRMs potentially useful when interpreting sequence analyses in clinical settings. The UL97 gene was sequenced from first/recurrent CMV infections among consecutive SOT or HSCT recipients during 2004-2009. GRMs were categorized as: Signature GRM (sGRM) if in vitro ganciclovir IC(50) ratio for mutated versus wild-type virus >2 (n = 24); polymorphic GRM (pGRM) if ratio ",
keywords = "Adult, Cytomegalovirus, Cytomegalovirus Infections, Drug Resistance, Viral, Female, Foscarnet, Ganciclovir, Hematopoietic Stem Cell Transplantation, Humans, Inhibitory Concentration 50, Male, Middle Aged, Mutation, Odds Ratio, Organ Transplantation, Phosphotransferases (Alcohol Group Acceptor), Prevalence, Recurrence, Risk Factors, Time Factors, Treatment Outcome, Young Adult",
author = "Cunha-Bang, {C da} and N Kirkby and M S{\o}nderholm and S{\o}rensen, {S S} and H Sengel{\o}v and M Iversen and A Rasmussen and F Gustafsson and Frederiksen, {C M} and J Kjaer and Lepri, {A Cozzi} and Lundgren, {J D}",
note = "{\textcopyright} Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons.",
year = "2013",
month = feb,
doi = "10.1111/ajt.12042",
language = "English",
volume = "13",
pages = "458--66",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection

AU - Cunha-Bang, C da

AU - Kirkby, N

AU - Sønderholm, M

AU - Sørensen, S S

AU - Sengeløv, H

AU - Iversen, M

AU - Rasmussen, A

AU - Gustafsson, F

AU - Frederiksen, C M

AU - Kjaer, J

AU - Lepri, A Cozzi

AU - Lundgren, J D

N1 - © Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons.

PY - 2013/2

Y1 - 2013/2

N2 - (Val)ganciclovir is used to treat cytomegalovirus (CMV) infection following solid organ (SOT) or hematopoietic stem cell (HSCT) transplantation. Treatment failures occur, but the contribution from 39 known ganciclovir-related mutations (GRMs) in the CMV-UL97 gene remains controversial. We propose a categorization of these GRMs potentially useful when interpreting sequence analyses in clinical settings. The UL97 gene was sequenced from first/recurrent CMV infections among consecutive SOT or HSCT recipients during 2004-2009. GRMs were categorized as: Signature GRM (sGRM) if in vitro ganciclovir IC(50) ratio for mutated versus wild-type virus >2 (n = 24); polymorphic GRM (pGRM) if ratio

AB - (Val)ganciclovir is used to treat cytomegalovirus (CMV) infection following solid organ (SOT) or hematopoietic stem cell (HSCT) transplantation. Treatment failures occur, but the contribution from 39 known ganciclovir-related mutations (GRMs) in the CMV-UL97 gene remains controversial. We propose a categorization of these GRMs potentially useful when interpreting sequence analyses in clinical settings. The UL97 gene was sequenced from first/recurrent CMV infections among consecutive SOT or HSCT recipients during 2004-2009. GRMs were categorized as: Signature GRM (sGRM) if in vitro ganciclovir IC(50) ratio for mutated versus wild-type virus >2 (n = 24); polymorphic GRM (pGRM) if ratio

KW - Adult

KW - Cytomegalovirus

KW - Cytomegalovirus Infections

KW - Drug Resistance, Viral

KW - Female

KW - Foscarnet

KW - Ganciclovir

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Inhibitory Concentration 50

KW - Male

KW - Middle Aged

KW - Mutation

KW - Odds Ratio

KW - Organ Transplantation

KW - Phosphotransferases (Alcohol Group Acceptor)

KW - Prevalence

KW - Recurrence

KW - Risk Factors

KW - Time Factors

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1111/ajt.12042

DO - 10.1111/ajt.12042

M3 - Journal article

C2 - 23282281

VL - 13

SP - 458

EP - 466

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 2

ER -

ID: 105597872