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The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. / Helgadottir, Anna; Thorleifsson, Gudmar; Magnusson, Kristinn P; Grétarsdottir, Solveig; Steinthorsdottir, Valgerdur; Manolescu, Andrei; Jones, Gregory T; Rinkel, Gabriel J E; Blankensteijn, Jan D; Ronkainen, Antti; Jääskeläinen, Juha E; Kyo, Yoshiki; Lenk, Guy M; Sakalihasan, Natzi; Kostulas, Konstantinos; Gottsäter, Anders; Flex, Andrea; Stefansson, Hreinn; Hansen, Torben; Andersen, Gitte; Weinsheimer, Shantel; Borch-Johnsen, Knut; Jørgensen, Torben; Shah, Svati H; Quyyumi, Arshed A; Granger, Christopher B; Reilly, Muredach P; Austin, Harland; Levey, Allan I; Vaccarino, Viola; Palsdottir, Ebba; Walters, G Bragi; Jonsdottir, Thorbjorg; Snorradottir, Steinunn; Magnusdottir, Dana; Gudmundsson, Gudmundur; Ferrell, Robert E; Sveinbjornsdottir, Sigurlaug; Hernesniemi, Juha; Niemelä, Mika; Limet, Raymond; Andersen, Karl; Sigurdsson, Gunnar; Benediktsson, Rafn; Verhoeven, Eric L G; Teijink, Joep A W; Grobbee, Diederick E; Rader, Daniel J; Collier, David A; Pedersen, Oluf; Pola, Roberto; Hillert, Jan; Lindblad, Bengt; Valdimarsson, Einar M; Magnadottir, Hulda B; Wijmenga, Cisca; Tromp, Gerard; Baas, Annette F; Ruigrok, Ynte M; van Rij, Andre M; Kuivaniemi, Helena; Powell, Janet T; Matthiasson, Stefan E; Gulcher, Jeffrey R; Thorgeirsson, Gudmundur; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari.
In:
Nature Genetics, Vol. 40, No. 2, 2008, p. 217-24.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Helgadottir, A, Thorleifsson, G, Magnusson, KP, Grétarsdottir, S, Steinthorsdottir, V, Manolescu, A, Jones, GT, Rinkel, GJE, Blankensteijn, JD, Ronkainen, A, Jääskeläinen, JE, Kyo, Y, Lenk, GM, Sakalihasan, N, Kostulas, K, Gottsäter, A, Flex, A, Stefansson, H
, Hansen, T, Andersen, G, Weinsheimer, S, Borch-Johnsen, K, Jørgensen, T, Shah, SH, Quyyumi, AA, Granger, CB, Reilly, MP, Austin, H, Levey, AI, Vaccarino, V, Palsdottir, E, Walters, GB, Jonsdottir, T, Snorradottir, S, Magnusdottir, D, Gudmundsson, G, Ferrell, RE, Sveinbjornsdottir, S, Hernesniemi, J, Niemelä, M, Limet, R, Andersen, K, Sigurdsson, G, Benediktsson, R, Verhoeven, ELG, Teijink, JAW, Grobbee, DE, Rader, DJ, Collier, DA
, Pedersen, O, Pola, R, Hillert, J, Lindblad, B, Valdimarsson, EM, Magnadottir, HB, Wijmenga, C, Tromp, G, Baas, AF, Ruigrok, YM, van Rij, AM, Kuivaniemi, H, Powell, JT, Matthiasson, SE, Gulcher, JR, Thorgeirsson, G, Kong, A, Thorsteinsdottir, U & Stefansson, K 2008, '
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm',
Nature Genetics, vol. 40, no. 2, pp. 217-24.
https://doi.org/10.1038/ng.72APA
Helgadottir, A., Thorleifsson, G., Magnusson, K. P., Grétarsdottir, S., Steinthorsdottir, V., Manolescu, A., Jones, G. T., Rinkel, G. J. E., Blankensteijn, J. D., Ronkainen, A., Jääskeläinen, J. E., Kyo, Y., Lenk, G. M., Sakalihasan, N., Kostulas, K., Gottsäter, A., Flex, A., Stefansson, H.
, Hansen, T., ... Stefansson, K. (2008).
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.
Nature Genetics,
40(2), 217-24.
https://doi.org/10.1038/ng.72Vancouver
Helgadottir A, Thorleifsson G, Magnusson KP, Grétarsdottir S, Steinthorsdottir V, Manolescu A et al.
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.
Nature Genetics. 2008;40(2):217-24.
https://doi.org/10.1038/ng.72Author
Helgadottir, Anna ; Thorleifsson, Gudmar ; Magnusson, Kristinn P ; Grétarsdottir, Solveig ; Steinthorsdottir, Valgerdur ; Manolescu, Andrei ; Jones, Gregory T ; Rinkel, Gabriel J E ; Blankensteijn, Jan D ; Ronkainen, Antti ; Jääskeläinen, Juha E ; Kyo, Yoshiki ; Lenk, Guy M ; Sakalihasan, Natzi ; Kostulas, Konstantinos ; Gottsäter, Anders ; Flex, Andrea ; Stefansson, Hreinn ; Hansen, Torben ; Andersen, Gitte ; Weinsheimer, Shantel ; Borch-Johnsen, Knut ; Jørgensen, Torben ; Shah, Svati H ; Quyyumi, Arshed A ; Granger, Christopher B ; Reilly, Muredach P ; Austin, Harland ; Levey, Allan I ; Vaccarino, Viola ; Palsdottir, Ebba ; Walters, G Bragi ; Jonsdottir, Thorbjorg ; Snorradottir, Steinunn ; Magnusdottir, Dana ; Gudmundsson, Gudmundur ; Ferrell, Robert E ; Sveinbjornsdottir, Sigurlaug ; Hernesniemi, Juha ; Niemelä, Mika ; Limet, Raymond ; Andersen, Karl ; Sigurdsson, Gunnar ; Benediktsson, Rafn ; Verhoeven, Eric L G ; Teijink, Joep A W ; Grobbee, Diederick E ; Rader, Daniel J ; Collier, David A ; Pedersen, Oluf ; Pola, Roberto ; Hillert, Jan ; Lindblad, Bengt ; Valdimarsson, Einar M ; Magnadottir, Hulda B ; Wijmenga, Cisca ; Tromp, Gerard ; Baas, Annette F ; Ruigrok, Ynte M ; van Rij, Andre M ; Kuivaniemi, Helena ; Powell, Janet T ; Matthiasson, Stefan E ; Gulcher, Jeffrey R ; Thorgeirsson, Gudmundur ; Kong, Augustine ; Thorsteinsdottir, Unnur ; Stefansson, Kari. / The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. In: Nature Genetics. 2008 ; Vol. 40, No. 2. pp. 217-24.
Bibtex
@article{940b623071ef11de8bc9000ea68e967b,
title = "The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm",
abstract = "Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.",
author = "Anna Helgadottir and Gudmar Thorleifsson and Magnusson, {Kristinn P} and Solveig Gr{\'e}tarsdottir and Valgerdur Steinthorsdottir and Andrei Manolescu and Jones, {Gregory T} and Rinkel, {Gabriel J E} and Blankensteijn, {Jan D} and Antti Ronkainen and J{\"a}{\"a}skel{\"a}inen, {Juha E} and Yoshiki Kyo and Lenk, {Guy M} and Natzi Sakalihasan and Konstantinos Kostulas and Anders Gotts{\"a}ter and Andrea Flex and Hreinn Stefansson and Torben Hansen and Gitte Andersen and Shantel Weinsheimer and Knut Borch-Johnsen and Torben J{\o}rgensen and Shah, {Svati H} and Quyyumi, {Arshed A} and Granger, {Christopher B} and Reilly, {Muredach P} and Harland Austin and Levey, {Allan I} and Viola Vaccarino and Ebba Palsdottir and Walters, {G Bragi} and Thorbjorg Jonsdottir and Steinunn Snorradottir and Dana Magnusdottir and Gudmundur Gudmundsson and Ferrell, {Robert E} and Sigurlaug Sveinbjornsdottir and Juha Hernesniemi and Mika Niemel{\"a} and Raymond Limet and Karl Andersen and Gunnar Sigurdsson and Rafn Benediktsson and Verhoeven, {Eric L G} and Teijink, {Joep A W} and Grobbee, {Diederick E} and Rader, {Daniel J} and Collier, {David A} and Oluf Pedersen and Roberto Pola and Jan Hillert and Bengt Lindblad and Valdimarsson, {Einar M} and Magnadottir, {Hulda B} and Cisca Wijmenga and Gerard Tromp and Baas, {Annette F} and Ruigrok, {Ynte M} and {van Rij}, {Andre M} and Helena Kuivaniemi and Powell, {Janet T} and Matthiasson, {Stefan E} and Gulcher, {Jeffrey R} and Gudmundur Thorgeirsson and Augustine Kong and Unnur Thorsteinsdottir and Kari Stefansson",
note = "Keywords: Adult; Aged; Alleles; Aortic Aneurysm, Abdominal; Case-Control Studies; Chi-Square Distribution; Chromosomes, Human, Pair 9; European Continental Ancestry Group; Female; Gene Frequency; Genetic Markers; Genetic Variation; Haplotypes; Homozygote; Humans; Intracranial Aneurysm; Likelihood Functions; Linkage Disequilibrium; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Polymorphism, Single Nucleotide; Prevalence; Probability; Risk Factors; Sequence Analysis, DNA",
year = "2008",
doi = "10.1038/ng.72",
language = "English",
volume = "40",
pages = "217--24",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "2",
}
RIS
TY - JOUR
T1 - The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
AU - Helgadottir, Anna
AU - Thorleifsson, Gudmar
AU - Magnusson, Kristinn P
AU - Grétarsdottir, Solveig
AU - Steinthorsdottir, Valgerdur
AU - Manolescu, Andrei
AU - Jones, Gregory T
AU - Rinkel, Gabriel J E
AU - Blankensteijn, Jan D
AU - Ronkainen, Antti
AU - Jääskeläinen, Juha E
AU - Kyo, Yoshiki
AU - Lenk, Guy M
AU - Sakalihasan, Natzi
AU - Kostulas, Konstantinos
AU - Gottsäter, Anders
AU - Flex, Andrea
AU - Stefansson, Hreinn
AU - Hansen, Torben
AU - Andersen, Gitte
AU - Weinsheimer, Shantel
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Shah, Svati H
AU - Quyyumi, Arshed A
AU - Granger, Christopher B
AU - Reilly, Muredach P
AU - Austin, Harland
AU - Levey, Allan I
AU - Vaccarino, Viola
AU - Palsdottir, Ebba
AU - Walters, G Bragi
AU - Jonsdottir, Thorbjorg
AU - Snorradottir, Steinunn
AU - Magnusdottir, Dana
AU - Gudmundsson, Gudmundur
AU - Ferrell, Robert E
AU - Sveinbjornsdottir, Sigurlaug
AU - Hernesniemi, Juha
AU - Niemelä, Mika
AU - Limet, Raymond
AU - Andersen, Karl
AU - Sigurdsson, Gunnar
AU - Benediktsson, Rafn
AU - Verhoeven, Eric L G
AU - Teijink, Joep A W
AU - Grobbee, Diederick E
AU - Rader, Daniel J
AU - Collier, David A
AU - Pedersen, Oluf
AU - Pola, Roberto
AU - Hillert, Jan
AU - Lindblad, Bengt
AU - Valdimarsson, Einar M
AU - Magnadottir, Hulda B
AU - Wijmenga, Cisca
AU - Tromp, Gerard
AU - Baas, Annette F
AU - Ruigrok, Ynte M
AU - van Rij, Andre M
AU - Kuivaniemi, Helena
AU - Powell, Janet T
AU - Matthiasson, Stefan E
AU - Gulcher, Jeffrey R
AU - Thorgeirsson, Gudmundur
AU - Kong, Augustine
AU - Thorsteinsdottir, Unnur
AU - Stefansson, Kari
N1 - Keywords: Adult; Aged; Alleles; Aortic Aneurysm, Abdominal; Case-Control Studies; Chi-Square Distribution; Chromosomes, Human, Pair 9; European Continental Ancestry Group; Female; Gene Frequency; Genetic Markers; Genetic Variation; Haplotypes; Homozygote; Humans; Intracranial Aneurysm; Likelihood Functions; Linkage Disequilibrium; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Polymorphism, Single Nucleotide; Prevalence; Probability; Risk Factors; Sequence Analysis, DNA
PY - 2008
Y1 - 2008
N2 - Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.
AB - Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.
U2 - 10.1038/ng.72
DO - 10.1038/ng.72
M3 - Journal article
C2 - 18176561
VL - 40
SP - 217
EP - 224
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 2
ER -
