The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion.

Research output: Contribution to journal › Journal article › Research

Standard

The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion. / Mogensen, T; Scott, N B; Lund, Claus; Bigler, D; Hjortsø, N C; Kehlet, H.

In: Anesthesia and Analgesia, Vol. 67, No. 8, 1988, p. 737-740.

Research output: Contribution to journal › Journal article › Research

Harvard

Mogensen, T, Scott, NB, Lund, C, Bigler, D, Hjortsø, NC & Kehlet, H 1988, 'The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion.', Anesthesia and Analgesia, vol. 67, no. 8, pp. 737-740. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3394960&query_hl=100>

APA

Mogensen, T., Scott, N. B., Lund, C., Bigler, D., Hjortsø, N. C., & Kehlet, H. (1988). The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion. Anesthesia and Analgesia, 67(8), 737-740. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3394960&query_hl=100

Vancouver

Mogensen T, Scott NB, Lund C, Bigler D, Hjortsø NC, Kehlet H. The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion. Anesthesia and Analgesia. 1988;67(8):737-740.

Author

Mogensen, T ; Scott, N B ; Lund, Claus ; Bigler, D ; Hjortsø, N C ; Kehlet, H. / The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion. In: Anesthesia and Analgesia. 1988 ; Vol. 67, No. 8. pp. 737-740.

Bibtex

@article{1b53d3222f3b4aaf8e7075a957fa2247,
title = "The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion.",
abstract = "The purpose of this study was to investigate whether regression of sensory analgesia during constant epidural bupivacaine infusion was different in postoperative patients with acute pain than in patients with chronic nonsurgical pain. Sensory levels of analgesia (to pinprick) and pain (on a five-point scale) were assessed hourly for 16 hours during continuous epidural infusion of 0.5% plain bupivacaine (8 ml/hr) in 12 patients with chronic nonsurgical pain and in 30 patients after major abdominal surgery performed under combined bupivacaine and halothane--N2O general anesthesia. No opiates were given. If sensory analgesia decreased more than five segments from the initial level or if the pain score reached 2 (moderate pain), the patient was removed from the study. Initial levels of sensory analgesia after loading doses of 21.8 +/- 0.5 and 19.3 +/- 0.8 ml bupivacaine 0.5% were similar (T3.8 +/- 0.3 and T3.8 +/- 0.5) in the surgical and chronic pain patients, respectively (mean +/- SEM). Of the surgical patients, only 4 of the 30 (13%) maintained the initial level of sensory analgesia, and a pain score below 2 throughout the study compared with 7 of the 12 patients with chronic pain (58%) (P less than 0.01). Mean duration of sensory blockade was significantly longer (P less than 0.005) in the patients with chronic pain than in surgical patients (13.1 +/- 1.2 and 8.5 +/- 0.7 hours, respectively). Thus, surgical injury hastens regression of sensory analgesia during continuous epidural bupivacaine infusion. The underlying mechanism remains to be determined.",
author = "T Mogensen and Scott, {N B} and Claus Lund and D Bigler and Hjorts{\o}, {N C} and H Kehlet",
year = "1988",
language = "English",
volume = "67",
pages = "737--740",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams & Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion.

AU - Mogensen, T

AU - Scott, N B

AU - Lund, Claus

AU - Bigler, D

AU - Hjortsø, N C

AU - Kehlet, H

PY - 1988

Y1 - 1988

N2 - The purpose of this study was to investigate whether regression of sensory analgesia during constant epidural bupivacaine infusion was different in postoperative patients with acute pain than in patients with chronic nonsurgical pain. Sensory levels of analgesia (to pinprick) and pain (on a five-point scale) were assessed hourly for 16 hours during continuous epidural infusion of 0.5% plain bupivacaine (8 ml/hr) in 12 patients with chronic nonsurgical pain and in 30 patients after major abdominal surgery performed under combined bupivacaine and halothane--N2O general anesthesia. No opiates were given. If sensory analgesia decreased more than five segments from the initial level or if the pain score reached 2 (moderate pain), the patient was removed from the study. Initial levels of sensory analgesia after loading doses of 21.8 +/- 0.5 and 19.3 +/- 0.8 ml bupivacaine 0.5% were similar (T3.8 +/- 0.3 and T3.8 +/- 0.5) in the surgical and chronic pain patients, respectively (mean +/- SEM). Of the surgical patients, only 4 of the 30 (13%) maintained the initial level of sensory analgesia, and a pain score below 2 throughout the study compared with 7 of the 12 patients with chronic pain (58%) (P less than 0.01). Mean duration of sensory blockade was significantly longer (P less than 0.005) in the patients with chronic pain than in surgical patients (13.1 +/- 1.2 and 8.5 +/- 0.7 hours, respectively). Thus, surgical injury hastens regression of sensory analgesia during continuous epidural bupivacaine infusion. The underlying mechanism remains to be determined.

AB - The purpose of this study was to investigate whether regression of sensory analgesia during constant epidural bupivacaine infusion was different in postoperative patients with acute pain than in patients with chronic nonsurgical pain. Sensory levels of analgesia (to pinprick) and pain (on a five-point scale) were assessed hourly for 16 hours during continuous epidural infusion of 0.5% plain bupivacaine (8 ml/hr) in 12 patients with chronic nonsurgical pain and in 30 patients after major abdominal surgery performed under combined bupivacaine and halothane--N2O general anesthesia. No opiates were given. If sensory analgesia decreased more than five segments from the initial level or if the pain score reached 2 (moderate pain), the patient was removed from the study. Initial levels of sensory analgesia after loading doses of 21.8 +/- 0.5 and 19.3 +/- 0.8 ml bupivacaine 0.5% were similar (T3.8 +/- 0.3 and T3.8 +/- 0.5) in the surgical and chronic pain patients, respectively (mean +/- SEM). Of the surgical patients, only 4 of the 30 (13%) maintained the initial level of sensory analgesia, and a pain score below 2 throughout the study compared with 7 of the 12 patients with chronic pain (58%) (P less than 0.01). Mean duration of sensory blockade was significantly longer (P less than 0.005) in the patients with chronic pain than in surgical patients (13.1 +/- 1.2 and 8.5 +/- 0.7 hours, respectively). Thus, surgical injury hastens regression of sensory analgesia during continuous epidural bupivacaine infusion. The underlying mechanism remains to be determined.

M3 - Journal article

VL - 67

SP - 737

EP - 740

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 8

ER -

ID: 40176219