The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms: Proteomics and Metabolomics Approaches

Research output: Contribution to journal › Review › Research › peer-review

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The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms : Proteomics and Metabolomics Approaches. / Cuevas-Cruz, Miguel; Hernández-Guzmán, Ulises; Álvarez-Rosales, Poulette Carolina; Schnabel, Meike; Gómez-Manzo, Saúl; Arreguín-Espinosa, Roberto.

In: Current Medicinal Chemistry, Vol. 30, No. 1, 2023, p. 30-58.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Cuevas-Cruz, M, Hernández-Guzmán, U, Álvarez-Rosales, PC, Schnabel, M, Gómez-Manzo, S & Arreguín-Espinosa, R 2023, 'The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms: Proteomics and Metabolomics Approaches', Current Medicinal Chemistry, vol. 30, no. 1, pp. 30-58. https://doi.org/10.2174/0929867329666220329090822

APA

Cuevas-Cruz, M., Hernández-Guzmán, U., Álvarez-Rosales, P. C., Schnabel, M., Gómez-Manzo, S., & Arreguín-Espinosa, R. (2023). The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms: Proteomics and Metabolomics Approaches. Current Medicinal Chemistry, 30(1), 30-58. https://doi.org/10.2174/0929867329666220329090822

Vancouver

Cuevas-Cruz M, Hernández-Guzmán U, Álvarez-Rosales PC, Schnabel M, Gómez-Manzo S, Arreguín-Espinosa R. The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms: Proteomics and Metabolomics Approaches. Current Medicinal Chemistry. 2023;30(1):30-58. https://doi.org/10.2174/0929867329666220329090822

Author

Cuevas-Cruz, Miguel ; Hernández-Guzmán, Ulises ; Álvarez-Rosales, Poulette Carolina ; Schnabel, Meike ; Gómez-Manzo, Saúl ; Arreguín-Espinosa, Roberto. / The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms : Proteomics and Metabolomics Approaches. In: Current Medicinal Chemistry. 2023 ; Vol. 30, No. 1. pp. 30-58.

Bibtex

@article{748d0d99c1e0448596f306e50bdeafe3,
title = "The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms: Proteomics and Metabolomics Approaches",
abstract = "The abuse and incorrect administration of antibiotics has resulted in an increased proliferation of bacteria that exhibit drug resistance. The emergence of resistant bacteria has become one of the biggest health concerns globally, and an enormous effort has been made to combat them. However, despite the efforts, the emergence of resistant strains is rapidly increasing, while the discovery of new classes of antibiotics has lagged. For this reason, it is pivotal to acquire a more detailed knowledge of bacterial resistance mechanisms and the mechanism of action of substances with antibacterial effects to identify biomarkers, therapeutic targets, and the development of new antibiotics. Metabolomics and proteomics, combined with mass spectrometry for data acquisition, are suitable techniques and have already been applied successfully. This review presents basic aspects of the metabolomic and proteomic approaches and their application for the elucidation of bacterial resistance mechanisms.",
keywords = "antibiotics, bacterial resistance, Mass spectrometry, metabolomics, proliferation, proteomics",
author = "Miguel Cuevas-Cruz and Ulises Hern{\'a}ndez-Guzm{\'a}n and {\'A}lvarez-Rosales, {Poulette Carolina} and Meike Schnabel and Sa{\'u}l G{\'o}mez-Manzo and Roberto Arregu{\'i}n-Espinosa",
note = "Publisher Copyright: {\textcopyright} 2023 Bentham Science Publishers.",
year = "2023",
doi = "10.2174/0929867329666220329090822",
language = "English",
volume = "30",
pages = "30--58",
journal = "Current Medicinal Chemistry",
issn = "0929-8673",
publisher = "Bentham Science Publishers",
number = "1",

}

RIS

TY - JOUR

T1 - The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms

T2 - Proteomics and Metabolomics Approaches

AU - Cuevas-Cruz, Miguel

AU - Hernández-Guzmán, Ulises

AU - Álvarez-Rosales, Poulette Carolina

AU - Schnabel, Meike

AU - Gómez-Manzo, Saúl

AU - Arreguín-Espinosa, Roberto

N1 - Publisher Copyright: © 2023 Bentham Science Publishers.

PY - 2023

Y1 - 2023

N2 - The abuse and incorrect administration of antibiotics has resulted in an increased proliferation of bacteria that exhibit drug resistance. The emergence of resistant bacteria has become one of the biggest health concerns globally, and an enormous effort has been made to combat them. However, despite the efforts, the emergence of resistant strains is rapidly increasing, while the discovery of new classes of antibiotics has lagged. For this reason, it is pivotal to acquire a more detailed knowledge of bacterial resistance mechanisms and the mechanism of action of substances with antibacterial effects to identify biomarkers, therapeutic targets, and the development of new antibiotics. Metabolomics and proteomics, combined with mass spectrometry for data acquisition, are suitable techniques and have already been applied successfully. This review presents basic aspects of the metabolomic and proteomic approaches and their application for the elucidation of bacterial resistance mechanisms.

AB - The abuse and incorrect administration of antibiotics has resulted in an increased proliferation of bacteria that exhibit drug resistance. The emergence of resistant bacteria has become one of the biggest health concerns globally, and an enormous effort has been made to combat them. However, despite the efforts, the emergence of resistant strains is rapidly increasing, while the discovery of new classes of antibiotics has lagged. For this reason, it is pivotal to acquire a more detailed knowledge of bacterial resistance mechanisms and the mechanism of action of substances with antibacterial effects to identify biomarkers, therapeutic targets, and the development of new antibiotics. Metabolomics and proteomics, combined with mass spectrometry for data acquisition, are suitable techniques and have already been applied successfully. This review presents basic aspects of the metabolomic and proteomic approaches and their application for the elucidation of bacterial resistance mechanisms.

KW - antibiotics

KW - bacterial resistance

KW - Mass spectrometry

KW - metabolomics

KW - proliferation

KW - proteomics

U2 - 10.2174/0929867329666220329090822

DO - 10.2174/0929867329666220329090822

M3 - Review

C2 - 35352637

AN - SCOPUS:85143984724

VL - 30

SP - 30

EP - 58

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

SN - 0929-8673

IS - 1

ER -

ID: 330891739