The RNA polymerase II transcription cycle: Cycling through chromatin
Research output: Contribution to journal › Review › Research › peer-review
The cycle of events that characterizes RNA polymerase II transcription has been the focus of intense study over the past two decades. Our knowledge of the molecular processes leading to transcriptional initiation is greatly improved, and the focus of many recent studies has shifted towards the less well-characterized events taking place after assembly of the pre-initiation complex, such as promoter clearance, elongation, and termination. This review gives a brief overview of the transcription cycle as a whole, focusing especially on selected mechanisms that may drive or restrict the cycle, and on how the presence of chromatin may influence these mechanisms.
Original language | English |
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Journal | Biochimica et Biophysica Acta - Gene Structure and Expression |
Volume | 1677 |
Issue number | 1-3 |
Pages (from-to) | 64-73 |
Number of pages | 10 |
ISSN | 0167-4781 |
DOIs | |
Publication status | Published - 15 Mar 2004 |
Externally published | Yes |
Bibliographical note
Funding Information:
Work in my laboratory is supported by grants from Cancer Research UK and the European Union (HPRN-CT-2000-00087). I apologise to colleagues whose work, due to the anecdotal character of this review, was not cited.
- C-terminal domain (CTD), Promoter clearance, RNA processing, Transcript elongation, Transcription cycle
Research areas
ID: 331040927