TY - JOUR

T1 - The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis

AU - Tognin, Stefania

AU - Richter, Anja

AU - Kempton, Matthew J.

AU - Modinos, Gemma

AU - Antoniades, Mathilde

AU - Azis, Matilda

AU - Allen, Paul

AU - Bossong, Matthijs G.

AU - Perez, Jesus

AU - Pantelis, Christos

AU - Nelson, Barnaby

AU - Amminger, Paul

AU - Riecher-Rössler, Anita

AU - Barrantes-Vidal, Neus

AU - Krebs, Marie Odile

AU - Glenthøj, Birte

AU - Ruhrmann, Stephan

AU - Sachs, Gabriele

AU - Rutten, Bart P.

AU - De Haan, Lieuwe

AU - Van Der Gaag, Mark

AU - Mcguire, Philip

AU - Valmaggia, Lucia R.

AU - Calem, Maria

AU - Antoniades, Mathilde

AU - Pisani, Sara

AU - Modinos, Gemma

AU - De Haan, Lieuwe

AU - Van Der Gaag, Mark

AU - Velthorst, Eva

AU - Kraan, Tamar C.

AU - Van Dam, Daniella S.

AU - Burger, Nadine

AU - Nelson, Barnaby

AU - Mcgorry, Patrick

AU - Amminger, G. Paul

AU - Politis, Athena

AU - Goodall, Joanne

AU - Riecher-Rössler, Anita

AU - Borgwardt, Stefan

AU - Studerus, Erich

AU - Bressan, Rodrigo

AU - Gadelha, Ary

AU - Brietzke, Elisa

AU - Asevedo, Graccielle

AU - Asevedo, Elson

AU - Zugman, Andre

AU - Barrantes-Vidal, Neus

AU - Domínguez-Martínez, Tecelli

AU - Racciopi, Anna

AU - Kwapil, Thomas R.

AU - Monsonet, Manel

AU - Hinojosa, Lídia

AU - Kazes, Mathilde

AU - Daban, Claire

AU - Bourgin, Julie

AU - Gay, Olivier

AU - Mam-Lam-Fook, Celia

AU - Krebs, Marie Odile

AU - Nordholm, Dorte

AU - Randers, Lasse

AU - Krakauer, Kristine

AU - Glenthøj, Louise

AU - Nordentoft, Merete

AU - Ruhrmann, Stephan

AU - Gebhard, Dominika

AU - Arnhold, Julia

AU - Klosterkötter, Joachim

AU - Sachs, Gabriele

AU - Lasser, Iris

AU - Winklbaur, Bernadette

AU - Aschauer, Harald

AU - Delespaul, Philippe A.

AU - Rutten, Bart P.

AU - Van Os, Jim

AU - Valmaggia, Lucia R.

AU - Mcguire, Philip

N1 - Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center.

PY - 2022

Y1 - 2022

N2 - Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. Results: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P <. 047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. Conclusions: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.

AB - Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. Results: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P <. 047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. Conclusions: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.

KW - clinical high risk for psychosis

KW - clinical outcomes

KW - functioning

KW - grey matter volume

KW - remission

KW - structural magnetic resonance imaging

KW - transition to psychosis

U2 - 10.1093/schizbullopen/sgac040

DO - 10.1093/schizbullopen/sgac040

M3 - Journal article

C2 - 35903803

AN - SCOPUS:85137055548

VL - 3

JO - Schizophrenia Bulletin Open

JF - Schizophrenia Bulletin Open

SN - 2632-7899

IS - 1

M1 - sgac040

ER -