The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis
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The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis. / Tognin, Stefania; Richter, Anja; Kempton, Matthew J.; Modinos, Gemma; Antoniades, Mathilde; Azis, Matilda; Allen, Paul; Bossong, Matthijs G.; Perez, Jesus; Pantelis, Christos; Nelson, Barnaby; Amminger, Paul; Riecher-Rössler, Anita; Barrantes-Vidal, Neus; Krebs, Marie Odile; Glenthøj, Birte; Ruhrmann, Stephan; Sachs, Gabriele; Rutten, Bart P.; De Haan, Lieuwe; Van Der Gaag, Mark; Mcguire, Philip; Valmaggia, Lucia R.; Calem, Maria; Antoniades, Mathilde; Pisani, Sara; Modinos, Gemma; De Haan, Lieuwe; Van Der Gaag, Mark; Velthorst, Eva; Kraan, Tamar C.; Van Dam, Daniella S.; Burger, Nadine; Nelson, Barnaby; Mcgorry, Patrick; Amminger, G. Paul; Politis, Athena; Goodall, Joanne; Riecher-Rössler, Anita; Borgwardt, Stefan; Studerus, Erich; Bressan, Rodrigo; Gadelha, Ary; Brietzke, Elisa; Asevedo, Graccielle; Asevedo, Elson; Zugman, Andre; Barrantes-Vidal, Neus; Domínguez-Martínez, Tecelli; Racciopi, Anna; Kwapil, Thomas R.; Monsonet, Manel; Hinojosa, Lídia; Kazes, Mathilde; Daban, Claire; Bourgin, Julie; Gay, Olivier; Mam-Lam-Fook, Celia; Krebs, Marie Odile; Nordholm, Dorte; Randers, Lasse; Krakauer, Kristine; Glenthøj, Louise; Nordentoft, Merete; Ruhrmann, Stephan; Gebhard, Dominika; Arnhold, Julia; Klosterkötter, Joachim; Sachs, Gabriele; Lasser, Iris; Winklbaur, Bernadette; Aschauer, Harald; Delespaul, Philippe A.; Rutten, Bart P.; Van Os, Jim; Valmaggia, Lucia R.; Mcguire, Philip.
In: Schizophrenia Bulletin Open, Vol. 3, No. 1, sgac040, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis
AU - Tognin, Stefania
AU - Richter, Anja
AU - Kempton, Matthew J.
AU - Modinos, Gemma
AU - Antoniades, Mathilde
AU - Azis, Matilda
AU - Allen, Paul
AU - Bossong, Matthijs G.
AU - Perez, Jesus
AU - Pantelis, Christos
AU - Nelson, Barnaby
AU - Amminger, Paul
AU - Riecher-Rössler, Anita
AU - Barrantes-Vidal, Neus
AU - Krebs, Marie Odile
AU - Glenthøj, Birte
AU - Ruhrmann, Stephan
AU - Sachs, Gabriele
AU - Rutten, Bart P.
AU - De Haan, Lieuwe
AU - Van Der Gaag, Mark
AU - Mcguire, Philip
AU - Valmaggia, Lucia R.
AU - Calem, Maria
AU - Antoniades, Mathilde
AU - Pisani, Sara
AU - Modinos, Gemma
AU - De Haan, Lieuwe
AU - Van Der Gaag, Mark
AU - Velthorst, Eva
AU - Kraan, Tamar C.
AU - Van Dam, Daniella S.
AU - Burger, Nadine
AU - Nelson, Barnaby
AU - Mcgorry, Patrick
AU - Amminger, G. Paul
AU - Politis, Athena
AU - Goodall, Joanne
AU - Riecher-Rössler, Anita
AU - Borgwardt, Stefan
AU - Studerus, Erich
AU - Bressan, Rodrigo
AU - Gadelha, Ary
AU - Brietzke, Elisa
AU - Asevedo, Graccielle
AU - Asevedo, Elson
AU - Zugman, Andre
AU - Barrantes-Vidal, Neus
AU - Domínguez-Martínez, Tecelli
AU - Racciopi, Anna
AU - Kwapil, Thomas R.
AU - Monsonet, Manel
AU - Hinojosa, Lídia
AU - Kazes, Mathilde
AU - Daban, Claire
AU - Bourgin, Julie
AU - Gay, Olivier
AU - Mam-Lam-Fook, Celia
AU - Krebs, Marie Odile
AU - Nordholm, Dorte
AU - Randers, Lasse
AU - Krakauer, Kristine
AU - Glenthøj, Louise
AU - Nordentoft, Merete
AU - Ruhrmann, Stephan
AU - Gebhard, Dominika
AU - Arnhold, Julia
AU - Klosterkötter, Joachim
AU - Sachs, Gabriele
AU - Lasser, Iris
AU - Winklbaur, Bernadette
AU - Aschauer, Harald
AU - Delespaul, Philippe A.
AU - Rutten, Bart P.
AU - Van Os, Jim
AU - Valmaggia, Lucia R.
AU - Mcguire, Philip
N1 - Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center.
PY - 2022
Y1 - 2022
N2 - Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. Results: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P <. 047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. Conclusions: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.
AB - Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. Results: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P <. 047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. Conclusions: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.
KW - clinical high risk for psychosis
KW - clinical outcomes
KW - functioning
KW - grey matter volume
KW - remission
KW - structural magnetic resonance imaging
KW - transition to psychosis
U2 - 10.1093/schizbullopen/sgac040
DO - 10.1093/schizbullopen/sgac040
M3 - Journal article
C2 - 35903803
AN - SCOPUS:85137055548
VL - 3
JO - Schizophrenia Bulletin Open
JF - Schizophrenia Bulletin Open
SN - 2632-7899
IS - 1
M1 - sgac040
ER -
ID: 334987698