The relationship between cerebral blood flow and volume in humans.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The relationship between cerebral blood flow and volume in humans. / Rostrup, Egill; Knudsen, Gitte M; Law, Ian; Holm, Søren; Larsson, Henrik B.W.; Paulson, Olaf B.

In: NeuroImage, Vol. 24, No. 1, 2005, p. 1-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rostrup, E, Knudsen, GM, Law, I, Holm, S, Larsson, HBW & Paulson, OB 2005, 'The relationship between cerebral blood flow and volume in humans.', NeuroImage, vol. 24, no. 1, pp. 1-11. <http://www.ncbi.nlm.nih.gov//entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15588591>

APA

Rostrup, E., Knudsen, G. M., Law, I., Holm, S., Larsson, H. B. W., & Paulson, O. B. (2005). The relationship between cerebral blood flow and volume in humans. NeuroImage, 24(1), 1-11. http://www.ncbi.nlm.nih.gov//entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15588591

Vancouver

Rostrup E, Knudsen GM, Law I, Holm S, Larsson HBW, Paulson OB. The relationship between cerebral blood flow and volume in humans. NeuroImage. 2005;24(1):1-11.

Author

Rostrup, Egill ; Knudsen, Gitte M ; Law, Ian ; Holm, Søren ; Larsson, Henrik B.W. ; Paulson, Olaf B. / The relationship between cerebral blood flow and volume in humans. In: NeuroImage. 2005 ; Vol. 24, No. 1. pp. 1-11.

Bibtex

@article{4c9252e39c9f4899906ce3a6f00cf5fe,
title = "The relationship between cerebral blood flow and volume in humans.",
abstract = "The purpose of this study was to establish the relationship between regional CBF and CBV at normal, resting cerebral metabolic rates. Eleven healthy volunteers were investigated with PET during baseline conditions, and during hyper- and hypocapnia. Values for rCBF and rCBV were obtained using (15)O-labelled water and carbon monoxide, respectively. The mean value of rCBF using PET was 62 +/- 18 ml.100 g(-1) min(-1) during baseline conditions, with an average increase of 46% during hypercapnia, and a decrease of 29% during hypocapnia; baseline rCBV was 7.7 ml/100 g, with 27% increase during hypercapnia and no significant decrease during hypocapnia. A regionally uniform exponential relationship was confirmed between P(a)CO(2) and rCBF as well as rCBV. It is shown that the theoretical implication of this is that the rCBV vs. rCBF relationship should be modelled by a power function; however, due to pronounced intersubject variability, the goodness of fit for linear and nonlinear models were not significantly different. The results of the study are applied to a numerical estimation of regional brain deoxy-haemoglobin content. Independently of the choice of model for the rCBV vs. rCBF relationship, a nonlinear deoxy-haemoglobin vs. rCBF relationship was predicted, and the implications for the BOLD response are discussed",
author = "Egill Rostrup and Knudsen, {Gitte M} and Ian Law and S{\o}ren Holm and Larsson, {Henrik B.W.} and Paulson, {Olaf B.}",
year = "2005",
language = "English",
volume = "24",
pages = "1--11",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - The relationship between cerebral blood flow and volume in humans.

AU - Rostrup, Egill

AU - Knudsen, Gitte M

AU - Law, Ian

AU - Holm, Søren

AU - Larsson, Henrik B.W.

AU - Paulson, Olaf B.

PY - 2005

Y1 - 2005

N2 - The purpose of this study was to establish the relationship between regional CBF and CBV at normal, resting cerebral metabolic rates. Eleven healthy volunteers were investigated with PET during baseline conditions, and during hyper- and hypocapnia. Values for rCBF and rCBV were obtained using (15)O-labelled water and carbon monoxide, respectively. The mean value of rCBF using PET was 62 +/- 18 ml.100 g(-1) min(-1) during baseline conditions, with an average increase of 46% during hypercapnia, and a decrease of 29% during hypocapnia; baseline rCBV was 7.7 ml/100 g, with 27% increase during hypercapnia and no significant decrease during hypocapnia. A regionally uniform exponential relationship was confirmed between P(a)CO(2) and rCBF as well as rCBV. It is shown that the theoretical implication of this is that the rCBV vs. rCBF relationship should be modelled by a power function; however, due to pronounced intersubject variability, the goodness of fit for linear and nonlinear models were not significantly different. The results of the study are applied to a numerical estimation of regional brain deoxy-haemoglobin content. Independently of the choice of model for the rCBV vs. rCBF relationship, a nonlinear deoxy-haemoglobin vs. rCBF relationship was predicted, and the implications for the BOLD response are discussed

AB - The purpose of this study was to establish the relationship between regional CBF and CBV at normal, resting cerebral metabolic rates. Eleven healthy volunteers were investigated with PET during baseline conditions, and during hyper- and hypocapnia. Values for rCBF and rCBV were obtained using (15)O-labelled water and carbon monoxide, respectively. The mean value of rCBF using PET was 62 +/- 18 ml.100 g(-1) min(-1) during baseline conditions, with an average increase of 46% during hypercapnia, and a decrease of 29% during hypocapnia; baseline rCBV was 7.7 ml/100 g, with 27% increase during hypercapnia and no significant decrease during hypocapnia. A regionally uniform exponential relationship was confirmed between P(a)CO(2) and rCBF as well as rCBV. It is shown that the theoretical implication of this is that the rCBV vs. rCBF relationship should be modelled by a power function; however, due to pronounced intersubject variability, the goodness of fit for linear and nonlinear models were not significantly different. The results of the study are applied to a numerical estimation of regional brain deoxy-haemoglobin content. Independently of the choice of model for the rCBV vs. rCBF relationship, a nonlinear deoxy-haemoglobin vs. rCBF relationship was predicted, and the implications for the BOLD response are discussed

M3 - Journal article

VL - 24

SP - 1

EP - 11

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 1

ER -

ID: 34057829