The Prevalence of Subtypes of Type 2 Inflammation in an Unselected Population of Patients with Severe Asthma
Research output: Contribution to journal › Journal article › Research › peer-review
Background: With the introduction of different targeted therapies for type 2 (T2)-high asthma, there is an urgent need for markers to guide the choice of treatment. T2-high asthma includes different clinical phenotypes of asthma, but the prevalence and impact of activation of different T2 inflammatory pathways is unknown. Objective: To describe the level of coexpression of clinically available T2 inflammatory markers in patients with severe asthma, and the relationship with clinical characteristics and comorbidities. Methods: Patients with severe asthma according to European Respiratory Society/American Thoracic Society guidelines were examined prospectively including sputum induction and grouped according to T2 biomarkers: blood eosinophilia (≥0.3 × 109/L), total IgE (≥150 U/mL), and fractional exhaled nitric oxide (≥25 parts per billion). Results: We found 116 (70%) of the 166 patients to have at least 1 T2 biomarker elevated: 39% had 2 or more elevated biomarkers, whereas 31% had only 1 biomarker elevated. Concomitant airway and systemic eosinophilia was present in 28% of all patients, corresponding to half (53%) of the patients with either. Expression patterns of the T2 biomarkers were associated with differences in allergic sensitization and the coexistence of nasal polyposis. Conclusions: Most patients with severe asthma showed at least 1 T2 inflammatory trait. Coexpression of T2 biomarkers was highly heterogeneous, and different expression patterns were associated with distinct clinical characteristics.
Original language | English |
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Journal | Journal of Allergy and Clinical Immunology: In Practice |
Volume | 9 |
Issue number | 3 |
Pages (from-to) | 1267-1275 |
Number of pages | 9 |
ISSN | 2213-2198 |
DOIs | |
Publication status | Published - Mar 2021 |
Bibliographical note
Publisher Copyright:
© 2020 American Academy of Allergy, Asthma & Immunology
- Biologics, Biomarkers, Heterogeneity, Phenotypes, Severe asthma, T2 inflammation
Research areas
ID: 285728318