The POU-er of gene nomenclature

Research output: Contribution to journal › Review › Research › peer-review

Standard

The POU-er of gene nomenclature. / Frankenberg, Stephen R; Frank, Dale; Harland, Richard; Johnson, Andrew D; Nichols, Jennifer; Niwa, Hitoshi; Schöler, Hans R; Tanaka, Elly; Wylie, Chris; Brickman, Joshua M.

In: Development (Cambridge, England), Vol. 141, No. 15, 08.2014, p. 2921-3.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Frankenberg, SR, Frank, D, Harland, R, Johnson, AD, Nichols, J, Niwa, H, Schöler, HR, Tanaka, E, Wylie, C & Brickman, JM 2014, 'The POU-er of gene nomenclature', Development (Cambridge, England), vol. 141, no. 15, pp. 2921-3. https://doi.org/10.1242/dev.108407

APA

Frankenberg, S. R., Frank, D., Harland, R., Johnson, A. D., Nichols, J., Niwa, H., Schöler, H. R., Tanaka, E., Wylie, C., & Brickman, J. M. (2014). The POU-er of gene nomenclature. Development (Cambridge, England), 141(15), 2921-3. https://doi.org/10.1242/dev.108407

Vancouver

Frankenberg SR, Frank D, Harland R, Johnson AD, Nichols J, Niwa H et al. The POU-er of gene nomenclature. Development (Cambridge, England). 2014 Aug;141(15):2921-3. https://doi.org/10.1242/dev.108407

Author

Frankenberg, Stephen R ; Frank, Dale ; Harland, Richard ; Johnson, Andrew D ; Nichols, Jennifer ; Niwa, Hitoshi ; Schöler, Hans R ; Tanaka, Elly ; Wylie, Chris ; Brickman, Joshua M. / The POU-er of gene nomenclature. In: Development (Cambridge, England). 2014 ; Vol. 141, No. 15. pp. 2921-3.

Bibtex

@article{40cab0a1813342459715139fdafb2af6,

title = "The POU-er of gene nomenclature",

abstract = "The pluripotency factor POU5F1 (OCT4) is well known as a key regulator of stem cell fate. Homologues of POU5F1 exist throughout vertebrates, but the evolutionary and functional relationships between the various family members have been unclear. The level to which function has been conserved within this family provides insight into the evolution of early embryonic potency. Here, we seek to clarify the relationship between POU5F1 homologues in the vertebrate lineage, both phylogenetically and functionally. We resolve the confusion over the identity of the zebrafish gene, which was originally named pou2, then changed to pou5f1 and again, more recently, to pou5f3. We argue that the use of correct nomenclature is crucial when discussing the degree to which the networks regulating early embryonic differentiation are conserved.",

author = "Frankenberg, {Stephen R} and Dale Frank and Richard Harland and Johnson, {Andrew D} and Jennifer Nichols and Hitoshi Niwa and Sch{\"o}ler, {Hans R} and Elly Tanaka and Chris Wylie and Brickman, {Joshua M}",

note = "{\textcopyright} 2014. Published by The Company of Biologists Ltd.",

year = "2014",

month = aug,

doi = "10.1242/dev.108407",

language = "English",

volume = "141",

pages = "2921--3",

journal = "Development",

issn = "0950-1991",

publisher = "The Company of Biologists",

number = "15",

}

RIS

TY - JOUR

T1 - The POU-er of gene nomenclature

AU - Frankenberg, Stephen R

AU - Frank, Dale

AU - Harland, Richard

AU - Johnson, Andrew D

AU - Nichols, Jennifer

AU - Niwa, Hitoshi

AU - Schöler, Hans R

AU - Tanaka, Elly

AU - Wylie, Chris

AU - Brickman, Joshua M

PY - 2014/8

Y1 - 2014/8

N2 - The pluripotency factor POU5F1 (OCT4) is well known as a key regulator of stem cell fate. Homologues of POU5F1 exist throughout vertebrates, but the evolutionary and functional relationships between the various family members have been unclear. The level to which function has been conserved within this family provides insight into the evolution of early embryonic potency. Here, we seek to clarify the relationship between POU5F1 homologues in the vertebrate lineage, both phylogenetically and functionally. We resolve the confusion over the identity of the zebrafish gene, which was originally named pou2, then changed to pou5f1 and again, more recently, to pou5f3. We argue that the use of correct nomenclature is crucial when discussing the degree to which the networks regulating early embryonic differentiation are conserved.

AB - The pluripotency factor POU5F1 (OCT4) is well known as a key regulator of stem cell fate. Homologues of POU5F1 exist throughout vertebrates, but the evolutionary and functional relationships between the various family members have been unclear. The level to which function has been conserved within this family provides insight into the evolution of early embryonic potency. Here, we seek to clarify the relationship between POU5F1 homologues in the vertebrate lineage, both phylogenetically and functionally. We resolve the confusion over the identity of the zebrafish gene, which was originally named pou2, then changed to pou5f1 and again, more recently, to pou5f3. We argue that the use of correct nomenclature is crucial when discussing the degree to which the networks regulating early embryonic differentiation are conserved.

U2 - 10.1242/dev.108407

DO - 10.1242/dev.108407

M3 - Review

C2 - 25053425

VL - 141

SP - 2921

EP - 2923

JO - Development

JF - Development

SN - 0950-1991

IS - 15

ER -

ID: 120735017

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