The potential of microRNAs as biofluid markers of neurodegenerative diseases – a systematic review
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The potential of microRNAs as biofluid markers of neurodegenerative diseases – a systematic review. / Danborg, Pia B; Simonsen, Anja H; Waldemar, Gunhild; Heegaard, Niels H H.
In: Biomarkers, Vol. 19, No. 4, 06.2014, p. 259-268.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The potential of microRNAs as biofluid markers of neurodegenerative diseases – a systematic review
AU - Danborg, Pia B
AU - Simonsen, Anja H
AU - Waldemar, Gunhild
AU - Heegaard, Niels H H
PY - 2014/6
Y1 - 2014/6
N2 - MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.
AB - MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.
KW - Biological Markers
KW - Cognition Disorders
KW - Humans
KW - MicroRNAs
KW - Neurodegenerative Diseases
U2 - 10.3109/1354750X.2014.904001
DO - 10.3109/1354750X.2014.904001
M3 - Review
C2 - 24678935
VL - 19
SP - 259
EP - 268
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 4
ER -
ID: 138620316