The P2X7 receptor: a key player in immune-mediated bone loss?
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
The P2X7 receptor : a key player in immune-mediated bone loss? / Kvist, Torben Madsen; Schwarz, Peter; Jørgensen, Niklas Rye.
In: Scientific World Journal, Vol. 2014, 2014, p. 1-11.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The P2X7 receptor
T2 - a key player in immune-mediated bone loss?
AU - Kvist, Torben Madsen
AU - Schwarz, Peter
AU - Jørgensen, Niklas Rye
PY - 2014
Y1 - 2014
N2 - Inflammatory diseases are often multiorganic diseases with manifestations not related directly to the primary affected organ. They are often complicated by a generalized bone loss that subsequently leads to osteoporosis and bone fractures. The exact mechanism for the accompanying bone loss is not understood in full detail, but factors such as glucocorticoid treatment, immobilization, malnutrition, and insufficient intake of vitamin D play a role. However, it has become evident that the inflammatory process itself is involved and the resulting bone loss is termed immune-mediated bone loss. It stems from an increase in bone resorption and the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1 beta and has been shown to not only mediate the inflammatory response but also to strongly stimulate bone degradation. The purinergic P2X7 receptor is central in the processing of these two cytokines and in the initiation of the inflammatory response, and it is a key molecule in the regulation of both bone formation and bone resorption. The aim of this review is therefore to provide evidence-based novel hypotheses of the role of ATP-mediated purinergic signalling via the P2X7 receptor in immune-mediated bone loss and -osteoporosis.
AB - Inflammatory diseases are often multiorganic diseases with manifestations not related directly to the primary affected organ. They are often complicated by a generalized bone loss that subsequently leads to osteoporosis and bone fractures. The exact mechanism for the accompanying bone loss is not understood in full detail, but factors such as glucocorticoid treatment, immobilization, malnutrition, and insufficient intake of vitamin D play a role. However, it has become evident that the inflammatory process itself is involved and the resulting bone loss is termed immune-mediated bone loss. It stems from an increase in bone resorption and the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1 beta and has been shown to not only mediate the inflammatory response but also to strongly stimulate bone degradation. The purinergic P2X7 receptor is central in the processing of these two cytokines and in the initiation of the inflammatory response, and it is a key molecule in the regulation of both bone formation and bone resorption. The aim of this review is therefore to provide evidence-based novel hypotheses of the role of ATP-mediated purinergic signalling via the P2X7 receptor in immune-mediated bone loss and -osteoporosis.
KW - Animals
KW - Cytokines
KW - Humans
KW - Inflammation
KW - Osteoporosis
KW - Receptors, Purinergic P2X7
U2 - 10.1155/2014/954530
DO - 10.1155/2014/954530
M3 - Journal article
C2 - 24574936
VL - 2014
SP - 1
EP - 11
JO - The Scientific World Journal
JF - The Scientific World Journal
SN - 2356-6140
ER -
ID: 137617673