The nucleotide sequence of the high-leukemogenic murine retrovirus SL3-3 reveals a patch of mink cell focus forming-like sequences upstream of the ecotropic envelope gene. Brief report.
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We report the complete nucleotide sequence of the potent T-lymphomagenic murine retrovirus SL3-3. The non-LTR regions of the virus show 98% sequence identity to the endogenous ecotropic Akv murine leukemia virus. While the region encoding the surface envelope protein is completely identical to that of Akv, a approximately 200 nucleotide stretch in the integrase encoding region upstream of env is similar to the sequence of mink cell focus forming (MCF) viruses and shows a complete match with the mouse retrovirus 10A1. The history of SL3-3 may therefore include recombination involving an Akv-like virus and a virus with MCF-like sequences.
Original language | English |
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Journal | Archives of Virology |
Volume | 144 |
Issue number | 11 |
Pages (from-to) | 2207-12 |
Number of pages | 5 |
ISSN | 0304-8608 |
Publication status | Published - 1999 |
Bibliographical note
Keywords: Animals; Base Sequence; DNA, Viral; Genes, env; Leukemia Virus, Murine; Mice; Mink Cell Focus-Inducing Viruses; Molecular Sequence Data
ID: 5016449