The microbiome in recurrent pregnancy loss – A scoping review
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The microbiome in recurrent pregnancy loss – A scoping review. / Vomstein, Kilian; Krog, Maria C.; Wrønding, Tine; Nielsen, Henriette Svarre.
In: Journal of Reproductive Immunology, Vol. 163, 104251, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The microbiome in recurrent pregnancy loss – A scoping review
AU - Vomstein, Kilian
AU - Krog, Maria C.
AU - Wrønding, Tine
AU - Nielsen, Henriette Svarre
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Recurrent pregnancy loss (RPL) is a troubling condition that affects couples worldwide. Despite extensive research efforts, many RPL cases remain unexplained, highlighting the need for novel approaches to unravel its underlying mechanisms. Recent advances in microbiome research have shed light on the potential role of the microbiome in reproductive health and outcomes. Based on a systematic literature research, this review aims to comprehensively explore the current understanding of the microbiome's involvement in RPL, focusing on the vaginal, endometrial, and gut microbiomes. Evidence from the available studies is examined to explain the relationship between the microbiome and RPL. Furthermore, we discuss the diagnostic potential of the microbiome, therapeutic interventions, and future directions in microbiome research for RPL. Understanding the complex interactions between the microbiome and reproductive health holds promise for developing targeted interventions to help patients today diagnosed as unexplained.
AB - Recurrent pregnancy loss (RPL) is a troubling condition that affects couples worldwide. Despite extensive research efforts, many RPL cases remain unexplained, highlighting the need for novel approaches to unravel its underlying mechanisms. Recent advances in microbiome research have shed light on the potential role of the microbiome in reproductive health and outcomes. Based on a systematic literature research, this review aims to comprehensively explore the current understanding of the microbiome's involvement in RPL, focusing on the vaginal, endometrial, and gut microbiomes. Evidence from the available studies is examined to explain the relationship between the microbiome and RPL. Furthermore, we discuss the diagnostic potential of the microbiome, therapeutic interventions, and future directions in microbiome research for RPL. Understanding the complex interactions between the microbiome and reproductive health holds promise for developing targeted interventions to help patients today diagnosed as unexplained.
KW - Endometrium
KW - Microbiome
KW - Microbiota
KW - Miscarriage
KW - Pregnancy loss
KW - Vagina
U2 - 10.1016/j.jri.2024.104251
DO - 10.1016/j.jri.2024.104251
M3 - Journal article
C2 - 38718429
AN - SCOPUS:85192163201
VL - 163
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
SN - 0165-0378
M1 - 104251
ER -
ID: 391618950