The Met1-Linked Ubiquitin Machinery

Forskning

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

Research output: Contribution to journal › Review › Research › peer-review

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The Met1-Linked Ubiquitin Machinery : Emerging Themes of (De)regulation. / Hrdinka, Matous; Gyrd-Hansen, Mads.

In: Molecular Cell, Vol. 68, No. 2, 19.10.2017, p. 265-280.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hrdinka, M & Gyrd-Hansen, M 2017, 'The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation', Molecular Cell, vol. 68, no. 2, pp. 265-280. https://doi.org/10.1016/j.molcel.2017.09.001

APA

Hrdinka, M., & Gyrd-Hansen, M. (2017). The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation. Molecular Cell, 68(2), 265-280. https://doi.org/10.1016/j.molcel.2017.09.001

Vancouver

Hrdinka M, Gyrd-Hansen M. The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation. Molecular Cell. 2017 Oct 19;68(2):265-280. https://doi.org/10.1016/j.molcel.2017.09.001

Author

Hrdinka, Matous ; Gyrd-Hansen, Mads. / The Met1-Linked Ubiquitin Machinery : Emerging Themes of (De)regulation. In: Molecular Cell. 2017 ; Vol. 68, No. 2. pp. 265-280.

Bibtex

@article{0c699b5f02034ce98bdff9225039ff40,

title = "The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation",

abstract = "The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC.",

keywords = "Animals, Cell Death, Humans, Immunity, NF-kappa B/genetics, Neoplasm Proteins/immunology, Neoplasms/immunology, Polyubiquitin/genetics, Signal Transduction",

author = "Matous Hrdinka and Mads Gyrd-Hansen",

year = "2017",

month = oct,

day = "19",

doi = "10.1016/j.molcel.2017.09.001",

language = "English",

volume = "68",

pages = "265--280",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "2",

}

RIS

TY - JOUR

T1 - The Met1-Linked Ubiquitin Machinery

T2 - Emerging Themes of (De)regulation

AU - Hrdinka, Matous

AU - Gyrd-Hansen, Mads

PY - 2017/10/19

Y1 - 2017/10/19

N2 - The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC.

AB - The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC.

KW - Animals

KW - Cell Death

KW - Humans

KW - Immunity

KW - NF-kappa B/genetics

KW - Neoplasm Proteins/immunology

KW - Neoplasms/immunology

KW - Polyubiquitin/genetics

KW - Signal Transduction

U2 - 10.1016/j.molcel.2017.09.001

DO - 10.1016/j.molcel.2017.09.001

M3 - Review

C2 - 29053955

VL - 68

SP - 265

EP - 280

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 2

ER -

ID: 280717758