The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression
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The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression. / Bock, Camilla; Bukh, Jens Drachmann; Vinberg, Maj; Gether, Ulrik; Kessing, Lars Vedel; Bock, Camilla; Bukh, Jens Otto Drachmann; Vinberg, Maj; Kessing, Lars Vedel; Gether, Ulrik.
In: Psychopathology, Vol. 43, No. 3, 01.01.2010, p. 197-204.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression
AU - Bock, Camilla
AU - Bukh, Jens Drachmann
AU - Vinberg, Maj
AU - Gether, Ulrik
AU - Kessing, Lars Vedel
AU - Bock, Camilla
AU - Bukh, Jens Otto Drachmann
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
AU - Gether, Ulrik
N1 - Keywords: Adolescent; Adult; Aged; Antidepressive Agents; Depressive Disorder; Female; Humans; Interviews as Topic; Male; Middle Aged; Neurotic Disorders; Personality; Personality Assessment; Personality Disorders; Psychiatric Status Rating Scales; Questionnaires; Treatment Outcome
PY - 2010/1/1
Y1 - 2010/1/1
N2 - BACKGROUND: It has never been investigated whether comorbid personality disorder or neuroticism predicts a poor treatment outcome in first episode depression. METHODS: Medically treated patients discharged with a diagnosis of a single depressive episode from a psychiatric in- or outpatient hospital setting were consecutively sampled from the Danish Psychiatric Central Research Register. The patients participated in an extensive interview including the Schedules for Clinical Assessment in Neuropsychiatry, the Structured Clinical Interview for DSM-IV Axis II Personality Disorders and a detailed assessment of medical treatment history using standardised procedures (Treatment Response to Antidepressants Questionnaire, TRAQ). Remission was defined as a score of < or =7 on the Hamilton Depression Rating Scale, 17 items, and a score of > or =4 on the TRAQ following (1) a first adequate trial of antidepressant treatment, and (2) 2 trials of antidepressant treatment. Further personality traits were assessed by means of the Eysenck Personality Questionnaire. RESULTS: Among a total of 301 patients with a single depressive episode, 31.9% fulfilled diagnostic criteria for at least 1 personality disorder of any kind. Comorbid personality disorder was associated with a 2.2-times (95% CI: 1.1-4.2) increased risk of non-remission following the first antidepressant trial, whereas no effect was found following the second antidepressant trial (OR: 1.6; 95% CI: 0.8-3.4). A high level of neuroticism was associated with non-remission in first as well as second trials. CONCLUSION: Comorbid personality disorder and high levels of neuroticism in first episode depression predict an increased risk of non-remission from depression.
AB - BACKGROUND: It has never been investigated whether comorbid personality disorder or neuroticism predicts a poor treatment outcome in first episode depression. METHODS: Medically treated patients discharged with a diagnosis of a single depressive episode from a psychiatric in- or outpatient hospital setting were consecutively sampled from the Danish Psychiatric Central Research Register. The patients participated in an extensive interview including the Schedules for Clinical Assessment in Neuropsychiatry, the Structured Clinical Interview for DSM-IV Axis II Personality Disorders and a detailed assessment of medical treatment history using standardised procedures (Treatment Response to Antidepressants Questionnaire, TRAQ). Remission was defined as a score of < or =7 on the Hamilton Depression Rating Scale, 17 items, and a score of > or =4 on the TRAQ following (1) a first adequate trial of antidepressant treatment, and (2) 2 trials of antidepressant treatment. Further personality traits were assessed by means of the Eysenck Personality Questionnaire. RESULTS: Among a total of 301 patients with a single depressive episode, 31.9% fulfilled diagnostic criteria for at least 1 personality disorder of any kind. Comorbid personality disorder was associated with a 2.2-times (95% CI: 1.1-4.2) increased risk of non-remission following the first antidepressant trial, whereas no effect was found following the second antidepressant trial (OR: 1.6; 95% CI: 0.8-3.4). A high level of neuroticism was associated with non-remission in first as well as second trials. CONCLUSION: Comorbid personality disorder and high levels of neuroticism in first episode depression predict an increased risk of non-remission from depression.
U2 - 10.1159/000304176
DO - 10.1159/000304176
M3 - Journal article
C2 - 20375542
VL - 43
SP - 197
EP - 204
JO - Psychopathology
JF - Psychopathology
SN - 0254-4962
IS - 3
ER -
ID: 21701897