The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population. / Larsen, Margit Hørup; Zinyama, Rutendo; Kallestrup, Per; Gerstoft, Jan; Gomo, Exnevia; Thørner, Lise Wegner; Berg, Trine Baldorf; Erikstup, Christian; Ullum, Henrik.

In: Journal of Infectious Diseases, Vol. 207, No. 6, 2013, p. 903-06.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Larsen, MH, Zinyama, R, Kallestrup, P, Gerstoft, J, Gomo, E, Thørner, LW, Berg, TB, Erikstup, C & Ullum, H 2013, 'The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population', Journal of Infectious Diseases, vol. 207, no. 6, pp. 903-06. https://doi.org/10.1093/infdis/jis924

APA

Larsen, M. H., Zinyama, R., Kallestrup, P., Gerstoft, J., Gomo, E., Thørner, L. W., Berg, T. B., Erikstup, C., & Ullum, H. (2013). The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population. Journal of Infectious Diseases, 207(6), 903-06. https://doi.org/10.1093/infdis/jis924

Vancouver

Larsen MH, Zinyama R, Kallestrup P, Gerstoft J, Gomo E, Thørner LW et al. The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population. Journal of Infectious Diseases. 2013;207(6):903-06. https://doi.org/10.1093/infdis/jis924

Author

Larsen, Margit Hørup ; Zinyama, Rutendo ; Kallestrup, Per ; Gerstoft, Jan ; Gomo, Exnevia ; Thørner, Lise Wegner ; Berg, Trine Baldorf ; Erikstup, Christian ; Ullum, Henrik. / The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population. In: Journal of Infectious Diseases. 2013 ; Vol. 207, No. 6. pp. 903-06.

Bibtex

@article{60767065c4e8488288556ee5eb715b4d,
title = "The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population",
abstract = "We aimed to evaluate if the HLA-G 14-bp polymorphism (rs16375) has an impact on HIV progression and survival in an antiretroviral therapy (ART)-na{\"i}ve Zimbabwean cohort (n=312). Rs16375 was genotyped using a competitive allele-specific PCR system; CD4 cell counts and HIV RNA were measured by flow cytometry and commercially available PCR; survival was followed for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P=0.004), lower CD4 cell count (P=0.01), and increased mortality (hazard ratio=1.9, CI: 1.033-3.522; P=0.04) compared with HLA-G +14-bp carriers.",
author = "Larsen, {Margit H{\o}rup} and Rutendo Zinyama and Per Kallestrup and Jan Gerstoft and Exnevia Gomo and Th{\o}rner, {Lise Wegner} and Berg, {Trine Baldorf} and Christian Erikstup and Henrik Ullum",
year = "2013",
doi = "10.1093/infdis/jis924",
language = "English",
volume = "207",
pages = "903--06",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population

AU - Larsen, Margit Hørup

AU - Zinyama, Rutendo

AU - Kallestrup, Per

AU - Gerstoft, Jan

AU - Gomo, Exnevia

AU - Thørner, Lise Wegner

AU - Berg, Trine Baldorf

AU - Erikstup, Christian

AU - Ullum, Henrik

PY - 2013

Y1 - 2013

N2 - We aimed to evaluate if the HLA-G 14-bp polymorphism (rs16375) has an impact on HIV progression and survival in an antiretroviral therapy (ART)-naïve Zimbabwean cohort (n=312). Rs16375 was genotyped using a competitive allele-specific PCR system; CD4 cell counts and HIV RNA were measured by flow cytometry and commercially available PCR; survival was followed for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P=0.004), lower CD4 cell count (P=0.01), and increased mortality (hazard ratio=1.9, CI: 1.033-3.522; P=0.04) compared with HLA-G +14-bp carriers.

AB - We aimed to evaluate if the HLA-G 14-bp polymorphism (rs16375) has an impact on HIV progression and survival in an antiretroviral therapy (ART)-naïve Zimbabwean cohort (n=312). Rs16375 was genotyped using a competitive allele-specific PCR system; CD4 cell counts and HIV RNA were measured by flow cytometry and commercially available PCR; survival was followed for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P=0.004), lower CD4 cell count (P=0.01), and increased mortality (hazard ratio=1.9, CI: 1.033-3.522; P=0.04) compared with HLA-G +14-bp carriers.

U2 - 10.1093/infdis/jis924

DO - 10.1093/infdis/jis924

M3 - Journal article

C2 - 23264673

VL - 207

SP - 903

EP - 906

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 6

ER -

ID: 48451426