The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent Clostridioides difficile Infection: A Retrospective Cohort Study.
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The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent Clostridioides difficile Infection : A Retrospective Cohort Study. / Svensson, Camilla Kara; Cold, Frederik; Ribberholt, Iben; Zangenberg, Mike; Mirsepasi-Lauridsen, Hengameh Chloé; Petersen, Andreas Munk; Helms, Morten.
In: Cells, Vol. 11, No. 20, 3272, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent Clostridioides difficile Infection
T2 - A Retrospective Cohort Study.
AU - Svensson, Camilla Kara
AU - Cold, Frederik
AU - Ribberholt, Iben
AU - Zangenberg, Mike
AU - Mirsepasi-Lauridsen, Hengameh Chloé
AU - Petersen, Andreas Munk
AU - Helms, Morten
PY - 2022
Y1 - 2022
N2 - The most effective treatment for recurrent Clostridioides difficile infection (CDI) is faecal microbiota transplantation (FMT); however, the optimal route of administration is thus far unknown. This retrospective cohort study of 343 patients sought to evaluate the efficacy of treatment with FMT capsules, FMT enema, and rectal bacteriotherapy (RBT) during a five-year period. The primary endpoint was clinical resolution from CDI after eight weeks, and secondary endpoints were time to recurrence and death during the follow-up period. The proportion of patients with clinical resolution was 79.9% in the FMT capsule group, 53.3% in the FMT enema group, and 61.8% in the RBT group, corresponding to an adjusted odds ratio of 3.79 (CI: 1.82 to 8.26) in the FMT capsule group compared with FMT enema, and 2.92 (CI: 1.49 to 6.03) compared with RBT. The hazards ratio for recurrence within the first 12 months of follow-up was 0.24 (CI: 0.06 to 0.89) in the FMT capsule group compared with FMT enema, and 0.26 (CI: 0.08 to 0.91) compared with RBT. There was no difference in mortality. In conclusion, FMT capsules were more effective than both FMT enema and RBT as treatment of recurrent CDI and reduced the risk of further recurrences.
AB - The most effective treatment for recurrent Clostridioides difficile infection (CDI) is faecal microbiota transplantation (FMT); however, the optimal route of administration is thus far unknown. This retrospective cohort study of 343 patients sought to evaluate the efficacy of treatment with FMT capsules, FMT enema, and rectal bacteriotherapy (RBT) during a five-year period. The primary endpoint was clinical resolution from CDI after eight weeks, and secondary endpoints were time to recurrence and death during the follow-up period. The proportion of patients with clinical resolution was 79.9% in the FMT capsule group, 53.3% in the FMT enema group, and 61.8% in the RBT group, corresponding to an adjusted odds ratio of 3.79 (CI: 1.82 to 8.26) in the FMT capsule group compared with FMT enema, and 2.92 (CI: 1.49 to 6.03) compared with RBT. The hazards ratio for recurrence within the first 12 months of follow-up was 0.24 (CI: 0.06 to 0.89) in the FMT capsule group compared with FMT enema, and 0.26 (CI: 0.08 to 0.91) compared with RBT. There was no difference in mortality. In conclusion, FMT capsules were more effective than both FMT enema and RBT as treatment of recurrent CDI and reduced the risk of further recurrences.
KW - Humans
KW - Fecal Microbiota Transplantation/adverse effects
KW - Clostridioides difficile
KW - Retrospective Studies
KW - Clostridium Infections/therapy
KW - Treatment Outcome
U2 - 10.3390/cells11203272
DO - 10.3390/cells11203272
M3 - Journal article
C2 - 36291139
VL - 11
JO - Cells
JF - Cells
SN - 2073-4409
IS - 20
M1 - 3272
ER -
ID: 323839480