The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients
Research output: Contribution to journal › Journal article › Research › peer-review
The renal clearance of endogenous creatinine (CCr), sodium (CNa) and lithium (CLi) was determined before and after a single intravenous bolus of cimetidine in nine renal transplant recipients. The glomerular filtration rate (GFR) was measured with 125I-iothalamate clearance (CTh). The initial CCr of 65 ml/min (median) was reduced to a nadir of 46 ml/min (p less than 0.01) during the first 2 h after infusion of cimetidine. GFR remained unchanged, and thus the fractional clearance of creatinine (CCr/CTh) was reduced from 1.43 (median) to 1.03 (p less than 0.01). CNa and the fractional excretion of sodium decreased throughout the study (p less than 0.05); CLi was unchanged. In conclusion cimetidine, when measured during 1-h clearance periods, interferes with tubular creatinine secretion in the denervated kidney of transplant recipients without affecting the glomerular filtration rate or proximal tubular flow. This suggests that on-going cimetidine treatment must be taken into account when graft function is evaluated by the CCr alone.
Original language | English |
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Journal | Scandinavian Journal of Clinical & Laboratory Investigation |
Volume | 49 |
Issue number | 2 |
Pages (from-to) | 155-9 |
Number of pages | 5 |
ISSN | 0036-5513 |
Publication status | Published - Apr 1989 |
- Absorption, Adult, Cimetidine, Creatinine, Glomerular Filtration Rate, Humans, Kidney Transplantation, Kidney Tubules, Lithium, Male, Metabolic Clearance Rate, Middle Aged, Sodium
Research areas
ID: 47241146