The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study
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The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences : protocol for a dietary intervention study. / Senftleber, Ninna Karsbæk; Pedersen, Kristine Skøtt; Schnoor Jørgensen, Cecilie; Pedersen, Hanne; Bjerg Christensen, Marie Mathilde; Kabel Madsen, Emilie; Andersen, Kristine; Jørsboe, Emil; Gillum, Matthew Paul; Frøst, Michael Bom; Hansen, Torben; Jørgensen, Marit Eika.
In: International Journal of Circumpolar Health, Vol. 82, No. 1, 2178067, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences
T2 - protocol for a dietary intervention study
AU - Senftleber, Ninna Karsbæk
AU - Pedersen, Kristine Skøtt
AU - Schnoor Jørgensen, Cecilie
AU - Pedersen, Hanne
AU - Bjerg Christensen, Marie Mathilde
AU - Kabel Madsen, Emilie
AU - Andersen, Kristine
AU - Jørsboe, Emil
AU - Gillum, Matthew Paul
AU - Frøst, Michael Bom
AU - Hansen, Torben
AU - Jørgensen, Marit Eika
N1 - Funding Information: The study is funded by the Independent Research Fund Denmark (grant no. 1030-00363B), The Greenland Institute of Natural Resources (postdoctoral grant number 80.045), and The Greenlandic Research Council (research grant not numbered). Brugseni sponsored all foods for the dietary intervention and the ad libitum meal test. Publisher Copyright: © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656.
AB - In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656.
KW - Congenital sucrase-isomaltase deficiency
KW - dietary intervention
KW - food preferences
KW - greenland
KW - inuit diet
KW - metabolism
KW - microbiota
U2 - 10.1080/22423982.2023.2178067
DO - 10.1080/22423982.2023.2178067
M3 - Journal article
C2 - 38113483
AN - SCOPUS:85148658895
VL - 82
JO - International Journal of Circumpolar Health
JF - International Journal of Circumpolar Health
SN - 1239-9744
IS - 1
M1 - 2178067
ER -
ID: 338426077