The effect of nutritional supplementation on quality of life in people living with HIV: a randomized controlled trial
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The effect of nutritional supplementation on quality of life in people living with HIV : a randomized controlled trial. / Tesfaye Woldeyohannes, Markos; Kæstel, Pernille; Olsen, Mette Frahm; Girma, Tsinuel; Yilma, Daniel; Abdissa, Alemseged; Ritz, Christian; Michaelsen, Kim F.; Hanlon, Charlotte; Friis, Henrik.
In: Tropical Medicine & International Health, Vol. 21, No. 6, 2016, p. 735-742.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of nutritional supplementation on quality of life in people living with HIV
T2 - a randomized controlled trial
AU - Tesfaye Woldeyohannes, Markos
AU - Kæstel, Pernille
AU - Olsen, Mette Frahm
AU - Girma, Tsinuel
AU - Yilma, Daniel
AU - Abdissa, Alemseged
AU - Ritz, Christian
AU - Michaelsen, Kim F.
AU - Hanlon, Charlotte
AU - Friis, Henrik
N1 - CURIS 2016 NEXS 138
PY - 2016
Y1 - 2016
N2 - OBJECTIVE: To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART), and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months.METHODS: Randomized controlled trial in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17kg/m(2) and given daily supplements of 200 grams of LNS containing whey or soy either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality of life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, 3 and 6 months.RESULTS: Of the 282 participants, 186 (66.0%) were women. The mean age (standard deviation SD) was 32.8 (±9.0) years, and the mean (SD) total quality of life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS [β=6.2, 95% confidence interval: 2.9: 9.6]. At 6 months, there was no difference in total quality of life score between the early and delayed supplementation groups [β=3.0, 95% confidence interval: -0.4: 6.4]. However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group.CONCLUSIONS: LNS given during the first 4 months of ART improves the quality of life of PLHIV. This article is protected by copyright. All rights reserved.
AB - OBJECTIVE: To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART), and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months.METHODS: Randomized controlled trial in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17kg/m(2) and given daily supplements of 200 grams of LNS containing whey or soy either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality of life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, 3 and 6 months.RESULTS: Of the 282 participants, 186 (66.0%) were women. The mean age (standard deviation SD) was 32.8 (±9.0) years, and the mean (SD) total quality of life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS [β=6.2, 95% confidence interval: 2.9: 9.6]. At 6 months, there was no difference in total quality of life score between the early and delayed supplementation groups [β=3.0, 95% confidence interval: -0.4: 6.4]. However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group.CONCLUSIONS: LNS given during the first 4 months of ART improves the quality of life of PLHIV. This article is protected by copyright. All rights reserved.
U2 - 10.1111/tmi.12705
DO - 10.1111/tmi.12705
M3 - Journal article
C2 - 27115126
VL - 21
SP - 735
EP - 742
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
SN - 1360-2276
IS - 6
ER -
ID: 160999083