The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial
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BACKGROUND: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. METHODS: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. RESULTS: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. CONCLUSIONS: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.
Original language | English |
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Journal | Anesthesia and Analgesia |
Volume | 108 |
Issue number | 4 |
Pages (from-to) | 1152-6 |
Number of pages | 4 |
ISSN | 0003-2999 |
DOIs | |
Publication status | Published - 2009 |
Bibliographical note
Keywords: Administration, Oral; Adult; Ambulatory Surgical Procedures; Cholecystectomy, Laparoscopic; Double-Blind Method; Drug Administration Schedule; Fatigue; Female; Humans; Hypnotics and Sedatives; Male; Melatonin; Middle Aged; Pain Measurement; Pain, Postoperative; Sleep; Surgical Procedures, Elective; Time Factors; Treatment Outcome
ID: 19440825