The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial. / Gögenur, Ismail; Kücükakin, Bülent; Bisgaard, Thue; Kristiansen, Viggo; Hjortsø, Niels-Christian; Skene, Debra J; Rosenberg, Jacob.

In: Anesthesia and Analgesia, Vol. 108, No. 4, 2009, p. 1152-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gögenur, I, Kücükakin, B, Bisgaard, T, Kristiansen, V, Hjortsø, N-C, Skene, DJ & Rosenberg, J 2009, 'The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial', Anesthesia and Analgesia, vol. 108, no. 4, pp. 1152-6. https://doi.org/10.1213/ane.0b013e31819a6cf0

APA

Gögenur, I., Kücükakin, B., Bisgaard, T., Kristiansen, V., Hjortsø, N-C., Skene, D. J., & Rosenberg, J. (2009). The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial. Anesthesia and Analgesia, 108(4), 1152-6. https://doi.org/10.1213/ane.0b013e31819a6cf0

Vancouver

Gögenur I, Kücükakin B, Bisgaard T, Kristiansen V, Hjortsø N-C, Skene DJ et al. The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial. Anesthesia and Analgesia. 2009;108(4):1152-6. https://doi.org/10.1213/ane.0b013e31819a6cf0

Author

Gögenur, Ismail ; Kücükakin, Bülent ; Bisgaard, Thue ; Kristiansen, Viggo ; Hjortsø, Niels-Christian ; Skene, Debra J ; Rosenberg, Jacob. / The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial. In: Anesthesia and Analgesia. 2009 ; Vol. 108, No. 4. pp. 1152-6.

Bibtex

@article{575edc60538311df928f000ea68e967b,
title = "The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial",
abstract = "BACKGROUND: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. METHODS: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. RESULTS: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. CONCLUSIONS: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.",
author = "Ismail G{\"o}genur and B{\"u}lent K{\"u}c{\"u}kakin and Thue Bisgaard and Viggo Kristiansen and Niels-Christian Hjorts{\o} and Skene, {Debra J} and Jacob Rosenberg",
note = "Keywords: Administration, Oral; Adult; Ambulatory Surgical Procedures; Cholecystectomy, Laparoscopic; Double-Blind Method; Drug Administration Schedule; Fatigue; Female; Humans; Hypnotics and Sedatives; Male; Melatonin; Middle Aged; Pain Measurement; Pain, Postoperative; Sleep; Surgical Procedures, Elective; Time Factors; Treatment Outcome",
year = "2009",
doi = "10.1213/ane.0b013e31819a6cf0",
language = "English",
volume = "108",
pages = "1152--6",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial

AU - Gögenur, Ismail

AU - Kücükakin, Bülent

AU - Bisgaard, Thue

AU - Kristiansen, Viggo

AU - Hjortsø, Niels-Christian

AU - Skene, Debra J

AU - Rosenberg, Jacob

N1 - Keywords: Administration, Oral; Adult; Ambulatory Surgical Procedures; Cholecystectomy, Laparoscopic; Double-Blind Method; Drug Administration Schedule; Fatigue; Female; Humans; Hypnotics and Sedatives; Male; Melatonin; Middle Aged; Pain Measurement; Pain, Postoperative; Sleep; Surgical Procedures, Elective; Time Factors; Treatment Outcome

PY - 2009

Y1 - 2009

N2 - BACKGROUND: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. METHODS: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. RESULTS: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. CONCLUSIONS: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.

AB - BACKGROUND: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. METHODS: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. RESULTS: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. CONCLUSIONS: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.

U2 - 10.1213/ane.0b013e31819a6cf0

DO - 10.1213/ane.0b013e31819a6cf0

M3 - Journal article

C2 - 19299778

VL - 108

SP - 1152

EP - 1156

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 4

ER -

ID: 19440825