The effect of gestational age on major neurodevelopmental disorders in preterm infants
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
The effect of gestational age on major neurodevelopmental disorders in preterm infants. / Larsen, Mads L.; Wiingreen, Rikke; Jensen, Andreas; Rackauskaite, Gija; Laursen, Bjarne; Hansen, Bo M.; Hoei-Hansen, Christina E.; Greisen, Gorm.
In: Pediatric Research, Vol. 91, 2022, p. 1906–1912.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The effect of gestational age on major neurodevelopmental disorders in preterm infants
AU - Larsen, Mads L.
AU - Wiingreen, Rikke
AU - Jensen, Andreas
AU - Rackauskaite, Gija
AU - Laursen, Bjarne
AU - Hansen, Bo M.
AU - Hoei-Hansen, Christina E.
AU - Greisen, Gorm
PY - 2022
Y1 - 2022
N2 - BackgroundPreterm infants have an increased risk of neurodevelopmental disorders. We established a direct quantitative comparison of the association between the degree of prematurity and three different neurodevelopmental disorders.MethodsIn this cohort study, we combined data from 995,498 children in the Danish Medical Birth Register, from birth years 1997–2013, with information on cerebral palsy, epilepsy, and special educational needs. We estimated the gestational week-specific prevalence and risk for each of the disorders.ResultsThe risk ratio of cerebral palsy at gestational weeks 21–24, compared to term birth, was more than ten times higher than for the two other disorders. The prevalence of epilepsy and special educational needs declined almost parallel, with 9.2% (4.6%–13.5%) and 12.5% (11.2%–13.7%), respectively, per week of gestation toward term birth. Cerebral palsy did not decline similarly: from gestational weeks 21–24 until week 29 the prevalence declined insignificantly by 0.6% (−11.1%–11.0%) per week; whereas from week 29 until term, the prevalence declined markedly by 36.7% (25.9%–45.9%) per week.ConclusionsThe prevalence and risk of cerebral palsy are affected differently by the degree of prematurity compared with epilepsy and special educational needs, possibly reflecting important differences in cerebral pathophysiology.
AB - BackgroundPreterm infants have an increased risk of neurodevelopmental disorders. We established a direct quantitative comparison of the association between the degree of prematurity and three different neurodevelopmental disorders.MethodsIn this cohort study, we combined data from 995,498 children in the Danish Medical Birth Register, from birth years 1997–2013, with information on cerebral palsy, epilepsy, and special educational needs. We estimated the gestational week-specific prevalence and risk for each of the disorders.ResultsThe risk ratio of cerebral palsy at gestational weeks 21–24, compared to term birth, was more than ten times higher than for the two other disorders. The prevalence of epilepsy and special educational needs declined almost parallel, with 9.2% (4.6%–13.5%) and 12.5% (11.2%–13.7%), respectively, per week of gestation toward term birth. Cerebral palsy did not decline similarly: from gestational weeks 21–24 until week 29 the prevalence declined insignificantly by 0.6% (−11.1%–11.0%) per week; whereas from week 29 until term, the prevalence declined markedly by 36.7% (25.9%–45.9%) per week.ConclusionsThe prevalence and risk of cerebral palsy are affected differently by the degree of prematurity compared with epilepsy and special educational needs, possibly reflecting important differences in cerebral pathophysiology.
U2 - 10.1038/s41390-021-01710-4
DO - 10.1038/s41390-021-01710-4
M3 - Journal article
C2 - 34420036
VL - 91
SP - 1906
EP - 1912
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
ER -
ID: 278488489