The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome: results from a randomised, double-blind, placebo-controlled study
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The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome : results from a randomised, double-blind, placebo-controlled study. / Madsen, Anna Maria Alcasid; Halkjaer, Sofie Ingdam; Christensen, Alice Højer; Guenther, Stig; Browne, Patrick Denis; Kallemose, Thomas; Hansen, Lars Hestbjerg; Petersen, Andreas Munk.
In: Scandinavian Journal of Gastroenterology, Vol. 56, No. 7, 2021, p. 761-769.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome
T2 - results from a randomised, double-blind, placebo-controlled study
AU - Madsen, Anna Maria Alcasid
AU - Halkjaer, Sofie Ingdam
AU - Christensen, Alice Højer
AU - Guenther, Stig
AU - Browne, Patrick Denis
AU - Kallemose, Thomas
AU - Hansen, Lars Hestbjerg
AU - Petersen, Andreas Munk
PY - 2021
Y1 - 2021
N2 - Background Irritable bowel syndrome (IBS) is associated with intestinal dysbiosis. Therefore, faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. In this study, we analysed previously unexamined data from our randomised, double-blind, placebo-controlled study (trial registration number NCT02788071). The objective was to evaluate the effect of FMT on abdominal pain, stool frequency, and stool form. Method The study included 52 adult patients with moderate-to-severe IBS assigned randomly to treatment with FMT capsules or placebo capsules (1:1) for 12 days. The patients were followed for a total of six months, during which they kept a daily symptom diary tracking their abdominal pain on a scale from 0-10 and their bowel movements using the Bristol Stool Form Scale (BSFS). Diary data were not collected before treatment start. Results A statistically significant improvement in stool frequency was found in the FMT group from during treatment to post-treatment and 1 month. No statistically significant differences were found between groups at any time during the study for any of abdominal pain, stool frequency, and stool form (as measured by weighted stool score). Conclusion In this analysis of results from a randomised, double-blind, placebo-controlled study, we found no clinically beneficial effect of FMT on abdominal pain, stool frequency, or stool form. However, since the current literature on the potential role of FMT in treating IBS shows conflicting results, further studies are required. To assess treatment efficacy, we recommend future studies to include daily symptom diaries both before and after treatment intervention.
AB - Background Irritable bowel syndrome (IBS) is associated with intestinal dysbiosis. Therefore, faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. In this study, we analysed previously unexamined data from our randomised, double-blind, placebo-controlled study (trial registration number NCT02788071). The objective was to evaluate the effect of FMT on abdominal pain, stool frequency, and stool form. Method The study included 52 adult patients with moderate-to-severe IBS assigned randomly to treatment with FMT capsules or placebo capsules (1:1) for 12 days. The patients were followed for a total of six months, during which they kept a daily symptom diary tracking their abdominal pain on a scale from 0-10 and their bowel movements using the Bristol Stool Form Scale (BSFS). Diary data were not collected before treatment start. Results A statistically significant improvement in stool frequency was found in the FMT group from during treatment to post-treatment and 1 month. No statistically significant differences were found between groups at any time during the study for any of abdominal pain, stool frequency, and stool form (as measured by weighted stool score). Conclusion In this analysis of results from a randomised, double-blind, placebo-controlled study, we found no clinically beneficial effect of FMT on abdominal pain, stool frequency, or stool form. However, since the current literature on the potential role of FMT in treating IBS shows conflicting results, further studies are required. To assess treatment efficacy, we recommend future studies to include daily symptom diaries both before and after treatment intervention.
KW - Faecal microbiota transplantation
KW - irritable bowel syndrome
KW - Bristol Stool Form Scale
KW - abdominal pain
KW - stool frequency
KW - IMPACT
U2 - 10.1080/00365521.2021.1915375
DO - 10.1080/00365521.2021.1915375
M3 - Journal article
C2 - 34000958
VL - 56
SP - 761
EP - 769
JO - Scandinavian Journal of Gastroenterology. Supplement
JF - Scandinavian Journal of Gastroenterology. Supplement
SN - 0085-5928
IS - 7
ER -
ID: 269609348