The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients
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The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients. / Bang, U.; Viby‐Mogensen, J.; Wirén, J. E.; Skovgaard, L. Theil.
In: Acta Anaesthesiologica Scandinavica Supplementum, Vol. 34, No. 7, 10.1990, p. 596-599.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium‐induced neuromuscular blockade in genotypically normal patients
AU - Bang, U.
AU - Viby‐Mogensen, J.
AU - Wirén, J. E.
AU - Skovgaard, L. Theil
PY - 1990/10
Y1 - 1990/10
N2 - Bambuterol (the bisdimethylcarbamate prodrug of terbutaline) is a new bronchodilator with a prolonged duration of action due to its inhibition of plasma cholinesterase during metabolism. The effect of bambuterol on suxamethonium‐induced neuromuscular blockade was studied in 10 patients undergoing elective laparotomy. Thirty mg of bambuterol was given 2 h before anaesthesia, which was performed with thiopentone, fentanyl, halothane and nitrous oxide in oxygen. Neuromuscular function was monitored using supramaximal train‐of‐four stimulation of the ulnar nerve and a force displacement transducer. Suxamethonium 1 mg ± kg‐1 was given i.v. for endotracheal intubation. Plasma cholinesterase activity was measured before and after intake of bambuterol and during anaesthesia. The results from the 10 patients were compared with those of 41 patients not given bambuterol but otherwise studied during the same conditions. Following bambuterol, all patients had a significant decrease of plasma cholinesterase activity (P< 0.001) and the suxamethonium‐induced blockade was 3–4 times prolonged compared to patients not given bambuterol (P<0.001). Five patients with very low plasma cholinesterase activity developed a long‐lasting phase II block.
AB - Bambuterol (the bisdimethylcarbamate prodrug of terbutaline) is a new bronchodilator with a prolonged duration of action due to its inhibition of plasma cholinesterase during metabolism. The effect of bambuterol on suxamethonium‐induced neuromuscular blockade was studied in 10 patients undergoing elective laparotomy. Thirty mg of bambuterol was given 2 h before anaesthesia, which was performed with thiopentone, fentanyl, halothane and nitrous oxide in oxygen. Neuromuscular function was monitored using supramaximal train‐of‐four stimulation of the ulnar nerve and a force displacement transducer. Suxamethonium 1 mg ± kg‐1 was given i.v. for endotracheal intubation. Plasma cholinesterase activity was measured before and after intake of bambuterol and during anaesthesia. The results from the 10 patients were compared with those of 41 patients not given bambuterol but otherwise studied during the same conditions. Following bambuterol, all patients had a significant decrease of plasma cholinesterase activity (P< 0.001) and the suxamethonium‐induced blockade was 3–4 times prolonged compared to patients not given bambuterol (P<0.001). Five patients with very low plasma cholinesterase activity developed a long‐lasting phase II block.
KW - Enzymes: plasma cholinesterase
KW - interactions: bambuterol
KW - monitoring: neuromuscuar function
KW - neuromuscular relaxants: succinylcholine
KW - pharmacology: bambuterol
KW - plasma cholinesterase
KW - succinyl‐choline
UR - http://www.scopus.com/inward/record.url?scp=0025144977&partnerID=8YFLogxK
U2 - 10.1111/j.1399-6576.1990.tb03152.x
DO - 10.1111/j.1399-6576.1990.tb03152.x
M3 - Journal article
C2 - 2244449
AN - SCOPUS:0025144977
VL - 34
SP - 596
EP - 599
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 7
ER -
ID: 259166101