The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: A randomized trial
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The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: A randomized trial. / Harder-Lauridsen, Nina Majlund; Nielsen, Signe Tellerup; Mann, Sebastian Porsdam; Lyngbæk, Mark Preben; Benatti, Fabiana Braga; Langkilde, Annika Reynberg; Law, Ian; Wedell-Neergaard, Anne Sophie; Thomsen, Carsten; Møller, Kirsten; Karstoft, Kristian; Pedersen, Bente Klarlund; Krogh-Madsen, Rikke.
In: Journal of Applied Physiology, Vol. 122, No. 2, 01.02.2017, p. 230-241.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: A randomized trial
AU - Harder-Lauridsen, Nina Majlund
AU - Nielsen, Signe Tellerup
AU - Mann, Sebastian Porsdam
AU - Lyngbæk, Mark Preben
AU - Benatti, Fabiana Braga
AU - Langkilde, Annika Reynberg
AU - Law, Ian
AU - Wedell-Neergaard, Anne Sophie
AU - Thomsen, Carsten
AU - Møller, Kirsten
AU - Karstoft, Kristian
AU - Pedersen, Bente Klarlund
AU - Krogh-Madsen, Rikke
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain,VO2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance. NEW & NOTEWORTHY Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.
AB - Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain,VO2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance. NEW & NOTEWORTHY Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.
KW - Alternate-day fasting
KW - Clinical
KW - Cognitive performance
KW - Inactivity
KW - Metabolism
KW - Oral glucose tolerance test
KW - Visceral fat mass
UR - https://www.mendeley.com/catalogue/cccb81bb-b339-32d5-81dc-5dae8e856df9/
U2 - 10.1152/japplphysiol.00846.2016
DO - 10.1152/japplphysiol.00846.2016
M3 - Journal article
C2 - 27881670
VL - 122
SP - 230
EP - 241
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 2
ER -
ID: 383104039