The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer
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The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer. / Bojesen, Rasmus Dahlin; Eriksen, Jens Ravn; Vogelsang, Rasmus Peuliche; Grube, Camilla; Forman, Julie Lyng; Gogenür, Ismail.
In: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, Vol. 23, No. 10, 2021, p. 2550-2558.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer
AU - Bojesen, Rasmus Dahlin
AU - Eriksen, Jens Ravn
AU - Vogelsang, Rasmus Peuliche
AU - Grube, Camilla
AU - Forman, Julie Lyng
AU - Gogenür, Ismail
N1 - This article is protected by copyright. All rights reserved.
PY - 2021
Y1 - 2021
N2 - AIM: The aim of this study was to describe the dynamic changes in blood work following individual adjusted dosage of intravenously administered iron(III)isomaltoside in a 4-week period prior to surgery in patients with colorectal cancer.METHODS: This was a single-center, observational cohort study with prospectively collected data, including patients with colorectal cancer receiving preoperative treatment with iron(III)isomaltoside. Blood samples were taken at baseline, one week, two weeks, and four weeks after initial treatment. Sixty-two patients were included in the study.RESULTS: Sixty-two patients were included for final analysis. The mean increase in haemoglobin was 0.77 g/dL (95% CI: 0.52-1.03, p<0.0001) at week 1, 1.5 g/dL (95% CI: 1.21-1.80, p<0.0001) at week 2, and 2.13 g/dL (95% CI: 1.71-2.55, p<0.0001) at week four. Patients with severe anaemia (<9.02 g/dL) showed the largest increase in haemoglobin during the treatment course (2.92 g/dL (95% CI: 2.27-3.58 g/dL, p<0.0001). Patients with mild anaemia (>10.31 g/dL) did not show a significant increase (0.66 g/dL (95% CI: -0.29-1.61, p=0.17) The mean of transferrin saturation after four weeks was 8% (95% CI: 6%-10%, p<0.0001).CONCLUSIONS: After intravenously administered iron, patients with severe anaemia had the most substantial increase in haemoglobin, and the increase was largest after four weeks. Patients with mild anemia did not have an increase in haemoglobin during the treatment course. The vast majority of patients still had iron deficiency at surgery four weeks after the initial treatment.
AB - AIM: The aim of this study was to describe the dynamic changes in blood work following individual adjusted dosage of intravenously administered iron(III)isomaltoside in a 4-week period prior to surgery in patients with colorectal cancer.METHODS: This was a single-center, observational cohort study with prospectively collected data, including patients with colorectal cancer receiving preoperative treatment with iron(III)isomaltoside. Blood samples were taken at baseline, one week, two weeks, and four weeks after initial treatment. Sixty-two patients were included in the study.RESULTS: Sixty-two patients were included for final analysis. The mean increase in haemoglobin was 0.77 g/dL (95% CI: 0.52-1.03, p<0.0001) at week 1, 1.5 g/dL (95% CI: 1.21-1.80, p<0.0001) at week 2, and 2.13 g/dL (95% CI: 1.71-2.55, p<0.0001) at week four. Patients with severe anaemia (<9.02 g/dL) showed the largest increase in haemoglobin during the treatment course (2.92 g/dL (95% CI: 2.27-3.58 g/dL, p<0.0001). Patients with mild anaemia (>10.31 g/dL) did not show a significant increase (0.66 g/dL (95% CI: -0.29-1.61, p=0.17) The mean of transferrin saturation after four weeks was 8% (95% CI: 6%-10%, p<0.0001).CONCLUSIONS: After intravenously administered iron, patients with severe anaemia had the most substantial increase in haemoglobin, and the increase was largest after four weeks. Patients with mild anemia did not have an increase in haemoglobin during the treatment course. The vast majority of patients still had iron deficiency at surgery four weeks after the initial treatment.
U2 - 10.1111/codi.15789
DO - 10.1111/codi.15789
M3 - Journal article
C2 - 34166572
VL - 23
SP - 2550
EP - 2558
JO - Colorectal Disease
JF - Colorectal Disease
SN - 1462-8910
IS - 10
ER -
ID: 273032459